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1ajv

From Proteopedia

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{{STRUCTURE_1ajv| PDB=1ajv | SCENE= }}
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'''HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC SULFAMIDE INHIBITOR AHA006'''
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===HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC SULFAMIDE INHIBITOR AHA006===
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==Overview==
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Two cyclic, C2-symmetric HIV-1 protease inhibitors, one sulfamide and one urea derivative, both comprising phenyl ether groups in the P1/P1' positions, were cocrystallized with HIV-1 protease, and the crystal structures were determined to 2.0 A resolution. The structure of the urea 2 showed a conformation similar to that reported for the related urea 3 by Lam et al., while the sulfamide 1 adopted an unanticipated conformation in which the P1' and P2' side chains were transposed.
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{{ABSTRACT_PUBMED_9083478}}
==About this Structure==
==About this Structure==
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[[Category: Non-peptide inhibitor]]
[[Category: Non-peptide inhibitor]]
[[Category: Protease]]
[[Category: Protease]]
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Revision as of 14:00, 30 June 2008

Image:1ajv.png

Template:STRUCTURE 1ajv

HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC SULFAMIDE INHIBITOR AHA006

Template:ABSTRACT PUBMED 9083478

About this Structure

1AJV is a Single protein structure of sequence from Human immunodeficiency virus type 1 (isolate 12). Full crystallographic information is available from OCA.

Reference

Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor., Backbro K, Lowgren S, Osterlund K, Atepo J, Unge T, Hulten J, Bonham NM, Schaal W, Karlen A, Hallberg A, J Med Chem. 1997 Mar 14;40(6):898-902. PMID:9083478

Page seeded by OCA on Mon Jun 30 17:00:14 2008

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