1akj

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{{STRUCTURE_1akj| PDB=1akj | SCENE= }}
{{STRUCTURE_1akj| PDB=1akj | SCENE= }}
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'''COMPLEX OF THE HUMAN MHC CLASS I GLYCOPROTEIN HLA-A2 AND THE T CELL CORECEPTOR CD8'''
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===COMPLEX OF THE HUMAN MHC CLASS I GLYCOPROTEIN HLA-A2 AND THE T CELL CORECEPTOR CD8===
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==Overview==
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The dimeric cell-surface glycoprotein CD8 is crucial to the positive selection of cytotoxic T cells in the thymus. The homodimer CD8alpha(alpha) or the heterodimer alpha beta stabilizes the interaction of the T-cell antigen receptor (TCR) with major histocompatibility complex (MHC) class I/peptide by binding to the class I molecule. Here we report the crystal structure at 2.7 A resolution of a complex between CD8alpha(alpha) and the human MHC molecule HLA-A2, which is associated with peptide. CD8alpha(alpha) binds one HLA-A2/peptide molecule, interfacing with the alpha2 and alpha3 domains of HLA-A2 and also contacting beta2-microglobulin. A flexible loop of the alpha3 domain (residues 223-229) is clamped between the complementarity-determining region (CDR)-like loops of the two CD8 subunits in the classic manner of an antibody-antigen interaction, precluding the binding of a second MHC molecule. The position of the alpha3 domain is different from that in uncomplexed HLA-A2, being most similar to that in the TCR/Tax/HLA-A2 complex, but no conformational change extends to the MHC/peptide surface presented for TCR recognition. Although these shifts in alpha3 may provide a synergistic modulation of affinity, the binding of CD8 to MHC is clearly consistent with an avidity-based contribution from CD8 to TCR-peptide-MHC interactions.
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(as it appears on PubMed at http://www.pubmed.gov), where 9177355 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9177355}}
==About this Structure==
==About this Structure==
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[[Category: Signal]]
[[Category: Signal]]
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[[Category: T-cell]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:02:18 2008''

Revision as of 14:02, 30 June 2008

Image:1akj.png

Template:STRUCTURE 1akj

COMPLEX OF THE HUMAN MHC CLASS I GLYCOPROTEIN HLA-A2 AND THE T CELL CORECEPTOR CD8

Template:ABSTRACT PUBMED 9177355

About this Structure

1AKJ is a Protein complex structure of sequences from Homo sapiens and Human immunodeficiency virus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2., Gao GF, Tormo J, Gerth UC, Wyer JR, McMichael AJ, Stuart DI, Bell JI, Jones EY, Jakobsen BK, Nature. 1997 Jun 5;387(6633):630-4. PMID:9177355

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