1dus

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Revision as of 11:28, 20 November 2007

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spinqualitylabelsall models 1dus, resolution 1.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

MJ0882-A hypothetical protein from M. jannaschii

Overview

We have determined the three-dimensional (3-D) structure of protein, MJ0882, which derives from a hypothetical open reading frame in the genome, of the hyperthermophile Methanococcus jannaschii. The 3-D fold of MJ0882, at 1.8 A highly resembles that of a methyltransferase, despite limited, sequence similarity to any confirmed methyltransferase. The structure has, an S-adenosylmethionine (AdoMet) binding pocket surrounded by motifs with, similarities to those commonly found among AdoMet binding proteins., Preliminary biochemical experiments show that MJ0882 specifically binds to, AdoMet, which is the essential co-factor for methyltransferases.

About this Structure

1DUS is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Reference

Structure-based experimental confirmation of biochemical function to a methyltransferase, MJ0882, from hyperthermophile Methanococcus jannaschii., Huang L, Hung L, Odell M, Yokota H, Kim R, Kim SH, J Struct Funct Genomics. 2002;2(3):121-7. PMID:12836702

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