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1al0

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[[Image:1al0.gif|left|200px]]
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{{Seed}}
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[[Image:1al0.png|left|200px]]
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{{STRUCTURE_1al0| PDB=1al0 | SCENE= }}
{{STRUCTURE_1al0| PDB=1al0 | SCENE= }}
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'''PROCAPSID OF BACTERIOPHAGE PHIX174'''
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===PROCAPSID OF BACTERIOPHAGE PHIX174===
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==Overview==
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The assembly of a macromolecular structure proceeds along an ordered morphogenetic pathway, and is accomplished by the switching of proteins between discrete conformations as they are added to the nascent assembly. Scaffolding proteins often play a catalytic role in the assembly process, rather like molecular chaperones. Although macromolecular assembly processes are fundamental to all biological systems, they have been characterized most thoroughly in viral systems, such as the icosahedral Escherichia coli bacteriophage phiX174. The phiX174 virion contains the proteins F, G, H and J. During assembly, two scaffoldingproteins B and D are required for the formation of a 108S, 360-A-diameter procapsid from pentameric precursors containing the F, G and H proteins. The procapsid contains 240 copies of protein D, forming an external scaffold, and 60 copies each of the internal scaffolding protein B, the capsid protein F, and the spike protein G. Maturation involves packaging of DNA and J proteins and loss of protein B, producing a 132S intermediate. Subsequent removal of the external scaffold yields the mature virion. Both the F and G proteins have the eight-stranded antiparallel beta-sandwich motif common to many plant and animal viruses. Here we describe the structure of a procapsid-like particle at 3.5-A resolution, showing how the scaffolding proteins coordinate assembly of the virus by interactions with the F and G proteins, and showing that the F protein undergoes conformational changes during capsid maturation.
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The line below this paragraph, {{ABSTRACT_PUBMED_9305849}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9305849 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9305849}}
==About this Structure==
==About this Structure==
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[[Category: Procapsid]]
[[Category: Procapsid]]
[[Category: Scaffolding protein]]
[[Category: Scaffolding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:24:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:04:16 2008''

Revision as of 14:04, 30 June 2008

Image:1al0.png

Template:STRUCTURE 1al0

PROCAPSID OF BACTERIOPHAGE PHIX174

Template:ABSTRACT PUBMED 9305849

About this Structure

1AL0 is a Protein complex structure of sequences from Enterobacteria phage phix174. Full crystallographic information is available from OCA.

Reference

Structure of a viral procapsid with molecular scaffolding., Dokland T, McKenna R, Ilag LL, Bowman BR, Incardona NL, Fane BA, Rossmann MG, Nature. 1997 Sep 18;389(6648):308-13. PMID:9305849

Page seeded by OCA on Mon Jun 30 17:04:16 2008

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