1al1

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[[Image:1al1.jpg|left|200px]]
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{{STRUCTURE_1al1| PDB=1al1 | SCENE= }}
{{STRUCTURE_1al1| PDB=1al1 | SCENE= }}
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'''CRYSTAL STRUCTURE OF ALPHA1: IMPLICATIONS FOR PROTEIN DESIGN'''
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===CRYSTAL STRUCTURE OF ALPHA1: IMPLICATIONS FOR PROTEIN DESIGN===
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==Overview==
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X-ray diffraction shows the structure of a synthetic protein model, formed from noncovalent self-association of a 12-residue peptide and of sulfate ions at low pH. This peptide is a fragment of a 16-residue polypeptide that was designed to form an amphiphilic alpha helix with a ridge of Leu residues along one helical face. By interdigitation of the leucines of four such helices, the design called for self-association into a four-alpha-helical bundle. The crystal structure (2.7 angstrom resolution; R factor = 0.215) reveals a structure more complex than the design, with both a tetramer and a hexamer. The alpha-helical tetramer with leucine interior has more oblique crossing angles than most four-alpha-helical bundles; the hexamer has a globular hydrophobic core of 12 leucine residues and three associated sulfate ions. Computational analysis suggests that the hexameric association is tighter than the tetrameric one. The consistency of the structure with the design is discussed, as well as the divergence.
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The line below this paragraph, {{ABSTRACT_PUBMED_2382133}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 2382133 is the PubMed ID number.
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{{ABSTRACT_PUBMED_2382133}}
==About this Structure==
==About this Structure==
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[[Category: Wesson, L.]]
[[Category: Wesson, L.]]
[[Category: Synthetic protein model]]
[[Category: Synthetic protein model]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:24:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:04:32 2008''

Revision as of 14:04, 30 June 2008

Image:1al1.png

Template:STRUCTURE 1al1

CRYSTAL STRUCTURE OF ALPHA1: IMPLICATIONS FOR PROTEIN DESIGN

Template:ABSTRACT PUBMED 2382133

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of alpha 1: implications for protein design., Hill CP, Anderson DH, Wesson L, DeGrado WF, Eisenberg D, Science. 1990 Aug 3;249(4968):543-6. PMID:2382133

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