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1ald

From Proteopedia

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[[Image:1ald.gif|left|200px]]
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{{STRUCTURE_1ald| PDB=1ald | SCENE= }}
{{STRUCTURE_1ald| PDB=1ald | SCENE= }}
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'''ACTIVITY AND SPECIFICITY OF HUMAN ALDOLASES'''
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===ACTIVITY AND SPECIFICITY OF HUMAN ALDOLASES===
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==Overview==
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The structure of the type I fructose 1,6-bisphosphate aldolase from human muscle has been extended from 3 A to 2 A resolution. The improvement in the resulting electron density map is such that the 20 or so C-terminal residues, known to be associated with activity and isozyme specificity, have been located. The side-chain of the Schiff's base-forming lysine 229 is located towards the centre of an eight-stranded beta-barrel type structure. The C-terminal "tail" extends from the rim of the beta-barrel towards lysine 229, thus forming part of the active site of the enzyme. This structural arrangement appears to explain the difference in activity and specificity of the three tissue-specific human aldolases and helps with our understanding of the type I aldolase reaction mechanism.
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(as it appears on PubMed at http://www.pubmed.gov), where 2056525 is the PubMed ID number.
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{{ABSTRACT_PUBMED_2056525}}
==About this Structure==
==About this Structure==
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Watson, H C.]]
[[Category: Watson, H C.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:25:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:05:29 2008''

Revision as of 14:05, 30 June 2008

Image:1ald.png

Template:STRUCTURE 1ald

ACTIVITY AND SPECIFICITY OF HUMAN ALDOLASES

Template:ABSTRACT PUBMED 2056525

About this Structure

1ALD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Activity and specificity of human aldolases., Gamblin SJ, Davies GJ, Grimes JM, Jackson RM, Littlechild JA, Watson HC, J Mol Biol. 1991 Jun 20;219(4):573-6. PMID:2056525

Page seeded by OCA on Mon Jun 30 17:05:29 2008

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