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1am7

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{{STRUCTURE_1am7| PDB=1am7 | SCENE= }}
{{STRUCTURE_1am7| PDB=1am7 | SCENE= }}
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'''LYSOZYME FROM BACTERIOPHAGE LAMBDA'''
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===LYSOZYME FROM BACTERIOPHAGE LAMBDA===
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==Overview==
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Like other lysozymes, the bacteriophage lambda lysozyme is involved in the digestion of bacterial walls. This enzyme is remarkable in that its mechanism of action is different from the classical lysozyme's mechanism. From the point of view of protein evolution, it shows features of lysozymes from different classes. The crystal structure of the enzyme in which all tryptophan residues have been replaced by aza-tryptophan has been solved by X-ray crystallography at 2.3 A using a combination of multiple isomorphous replacement, non-crystallographic symmetry averaging and density modification techniques. There are three molecules in the asymmetric unit. The characteristic structural elements of lysozymes are conserved: each molecule is organized in two domains connected by a helix and the essential catalytic residue (Glu19) is located in the depth of a cleft between the two domains. This cleft shows an open conformation in two of the independent molecules, while access to the cavity is much more restricted in the last one. A structural alignment with T4 lysozyme and hen egg white lysozyme allows us to superpose about 60 C alpha atoms with a rms distance close to 2 A. The best alignments concern the helix preceding the catalytic residue, some parts of the beta sheets and the helix joining the two domains. The results of sequence alignments with the V and C lysozymes, in which weak local similarities had been detected, are compared with the structural results.
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(as it appears on PubMed at http://www.pubmed.gov), where 9514719 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9514719}}
==About this Structure==
==About this Structure==
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[[Category: Lysozyme]]
[[Category: Lysozyme]]
[[Category: Transglycosylase]]
[[Category: Transglycosylase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:26:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:08:23 2008''

Revision as of 14:08, 30 June 2008

Image:1am7.png

Template:STRUCTURE 1am7

LYSOZYME FROM BACTERIOPHAGE LAMBDA

Template:ABSTRACT PUBMED 9514719

About this Structure

1AM7 is a Single protein structure of sequence from Enterobacteria phage lambda. Full crystallographic information is available from OCA.

Reference

Crystal structure of the lysozyme from bacteriophage lambda and its relationship with V and C-type lysozymes., Evrard C, Fastrez J, Declercq JP, J Mol Biol. 1998 Feb 13;276(1):151-64. PMID:9514719

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