1am9

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{{STRUCTURE_1am9| PDB=1am9 | SCENE= }}
{{STRUCTURE_1am9| PDB=1am9 | SCENE= }}
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'''HUMAN SREBP-1A BOUND TO LDL RECEPTOR PROMOTER'''
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===HUMAN SREBP-1A BOUND TO LDL RECEPTOR PROMOTER===
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==Overview==
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BACKGROUND: The sterol regulatory element binding proteins (SREBPs) are helix-loop-helix transcriptional activators that control expression of genes encoding proteins essential for cholesterol biosynthesis/uptake and fatty acid biosynthesis. Unlike helix-loop-helix proteins that recognize symmetric E-boxes (5'-CANNTG-3'), the SREBPs have a tyrosine instead of a conserved arginine in their basic regions. This difference allows recognition of an asymmetric sterol regulatory element (StRE, 5'-ATCACCCAC-3'). RESULTS: The 2.3 A resolution co-crystal structure of the DNA-binding portion of SREBP-1a bound to an StRE reveals a quasi-symmetric homodimer with an asymmetric DNA-protein interface. One monomer binds the E-box half site of the StRE (5'-ATCAC-3') using sidechain-base contacts typical of other helix-loop-helix proteins. The non-E-box half site (5'-GTGGG-3') is recognized through entirely different protein-DNA contacts. CONCLUSIONS: Although the SREBPs are structurally similar to the E-box-binding helix-loop-helix proteins, the Arg--&gt;Tyr substitution yields dramatically different DNA-binding properties that explain how they recognize StREs and regulate expression of genes important for membrane biosynthesis.
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The line below this paragraph, {{ABSTRACT_PUBMED_9634703}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9634703 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9634703}}
==About this Structure==
==About this Structure==
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[[Category: Sterol regulatory element binding protein]]
[[Category: Sterol regulatory element binding protein]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:26:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:08:31 2008''

Revision as of 14:08, 30 June 2008

Image:1am9.png

Template:STRUCTURE 1am9

HUMAN SREBP-1A BOUND TO LDL RECEPTOR PROMOTER

Template:ABSTRACT PUBMED 9634703

About this Structure

1AM9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 A resolution., Parraga A, Bellsolell L, Ferre-D'Amare AR, Burley SK, Structure. 1998 May 15;6(5):661-72. PMID:9634703

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