This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1an8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1an8.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1an8.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1an8| PDB=1an8 | SCENE= }}
{{STRUCTURE_1an8| PDB=1an8 | SCENE= }}
-
'''CRYSTAL STRUCTURE OF THE STREPTOCOCCAL SUPERANTIGEN SPE-C'''
+
===CRYSTAL STRUCTURE OF THE STREPTOCOCCAL SUPERANTIGEN SPE-C===
-
==Overview==
+
<!--
-
Bacterial superantigens are small proteins that have a very potent stimulatory effect on T lymphocytes through their ability to bind to both MHC class II molecules and T-cell receptors. We have determined the three-dimensional structure of a Streptococcal superantigen, SPE-C, at 2.4 A resolution. The structure shows that SPE-C has the usual superantigen fold, but that the surface that forms a generic, low-affinity MHC-binding site in other superantigens is here used to create a SPE-C dimer. Instead, MHC class II binding occurs through a zinc binding site that is analogous to a similar site in staphylococcal enterotoxin A. Consideration of the SPE-C dimer suggests a novel mechanism for promotion of MHC aggregation and T-cell activation.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9253413}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9253413 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9253413}}
==About this Structure==
==About this Structure==
Line 26: Line 30:
[[Category: Bacterial superantigen]]
[[Category: Bacterial superantigen]]
[[Category: Toxin]]
[[Category: Toxin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:28:25 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:12:26 2008''

Revision as of 14:12, 30 June 2008

Image:1an8.png

Template:STRUCTURE 1an8

CRYSTAL STRUCTURE OF THE STREPTOCOCCAL SUPERANTIGEN SPE-C

Template:ABSTRACT PUBMED 9253413

About this Structure

1AN8 is a Single protein structure of sequence from Streptococcus pyogenes. Full crystallographic information is available from OCA.

Reference

Crystal structure of the streptococcal superantigen SPE-C: dimerization and zinc binding suggest a novel mode of interaction with MHC class II molecules., Roussel A, Anderson BF, Baker HM, Fraser JD, Baker EN, Nat Struct Biol. 1997 Aug;4(8):635-43. PMID:9253413

Page seeded by OCA on Mon Jun 30 17:12:26 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1an8"
Personal tools