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1ant

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{{STRUCTURE_1ant| PDB=1ant | SCENE= }}
{{STRUCTURE_1ant| PDB=1ant | SCENE= }}
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'''BIOLOGICAL IMPLICATIONS OF A 3 ANGSTROMS STRUCTURE OF DIMERIC ANTITHROMBIN'''
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===BIOLOGICAL IMPLICATIONS OF A 3 ANGSTROMS STRUCTURE OF DIMERIC ANTITHROMBIN===
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==Overview==
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BACKGROUND: Antithrombin, a member of the serpin family of inhibitors, controls coagulation in human plasma by forming complexes with thrombin and other coagulation proteases in a process greatly accelerated by heparin. The structures of several serpins have been determined but not in their active conformations. We have determined the structure of intact antithrombin in order to study its mechanism of activation, particularly with respect to heparin, and the dysfunctions of this mechanism that predispose individuals to thrombotic disease. RESULTS: The crystal structure of a dimer of one active and one inactive molecule of antithrombin has been determined at 3 A. The first molecule has its reactive-centre loop in a predicted active conformation compatible with initial entry of two residues into the main beta-sheet of the molecule. The inactive molecule has a totally incorporated loop as in latent plasminogen activator inhibitor-1. The two molecules are linked by the reactive loop of the active molecule which has replaced a strand from another beta-sheet in the latent molecule. CONCLUSION: The structure, together with identified mutations affecting its heparin affinity, allows the placement of the heparin-binding site on the molecule. The conformation of the two forms of antithrombin demonstrates the extraordinary mobility of the reactive loop in the serpins and provides insights into the folding of the loop required for inhibitory activity together with the potential modification of this by heparin. The mechanism of dimerization is relevant to the polymerization that is observed in diseases associated with variant serpins.
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(as it appears on PubMed at http://www.pubmed.gov), where 8087553 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8087553}}
==About this Structure==
==About this Structure==
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[[Category: Wardell, M R.]]
[[Category: Wardell, M R.]]
[[Category: Serine protease inhibitor]]
[[Category: Serine protease inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:29:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:13:58 2008''

Revision as of 14:14, 30 June 2008

Image:1ant.png

Template:STRUCTURE 1ant

BIOLOGICAL IMPLICATIONS OF A 3 ANGSTROMS STRUCTURE OF DIMERIC ANTITHROMBIN

Template:ABSTRACT PUBMED 8087553

About this Structure

1ANT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Biological implications of a 3 A structure of dimeric antithrombin., Carrell RW, Stein PE, Fermi G, Wardell MR, Structure. 1994 Apr 15;2(4):257-70. PMID:8087553

Page seeded by OCA on Mon Jun 30 17:13:58 2008

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