1ao4

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{{STRUCTURE_1ao4| PDB=1ao4 | SCENE= }}
{{STRUCTURE_1ao4| PDB=1ao4 | SCENE= }}
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'''COBALT(III)-PEPLOMYCIN COMPLEX DETERMINED BY NMR STUDIES'''
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===COBALT(III)-PEPLOMYCIN COMPLEX DETERMINED BY NMR STUDIES===
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==Overview==
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Pepleomycin (PEP) is a metalloglycopeptide that has stronger anticancer activity and less pulmonary toxicity than bleomycin (BLM). PEP, like BLM, exerts its action by binding to and degrading DNA in the presence of oxygen and certain metals. Obtaining detailed structural information of PEP and PEP-DNA complexes is crucial to understanding its anticancer activity. The structures of two green forms of cobalt-PEP species, HO2-Co(III)-PEP (denoted CoPEP) and deglycosylated HO2-Co(III)-PEP (denoted CodPEP) have been obtained by NOE restrained refinements. Earlier studies of the related HO2-Co(III)-BLM A2 proposed that two chiral conformers (form A or B) could exist with either the beta-aminoalanine primary amine (A,NH2) or the mannose carbamoyl nitrogen (M,NH2) as the axial ligand. Analysis of our NOESY data shows convincingly that form A is the most probable conformer with the mannose carbamoyl M,NH2 and the beta-aminoalanine primary amine A,NH2 as the axial ligands in CoPEP and CodPEP, respectively. The NOE cross-peaks resulting from the interactions between the N-terminus (i.e., the metal-binding domain) and the C-terminus of CoPEP and CodPEP have similar patterns, suggesting that they both adopt compact structures with the bithiazole group folded back over the N-terminus.
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(as it appears on PubMed at http://www.pubmed.gov), where 9108252 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9108252}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AO4 OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AO4 OCA].
==Reference==
==Reference==
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[[Category: Solution structure]]
[[Category: Solution structure]]
[[Category: Two-dimensional nmr]]
[[Category: Two-dimensional nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:29:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:16:01 2008''

Revision as of 14:16, 30 June 2008

Image:1ao4.png

Template:STRUCTURE 1ao4

COBALT(III)-PEPLOMYCIN COMPLEX DETERMINED BY NMR STUDIES

Template:ABSTRACT PUBMED 9108252

About this Structure

Full experimental information is available from OCA.

Reference

Structures of cobalt(III)-pepleomycin and cobalt(III)-deglycopepleomycin (green forms) determined by NMR studies., Caceres-Cortes J, Sugiyama H, Ikudome K, Saito I, Wang AH, Eur J Biochem. 1997 Mar 15;244(3):818-28. PMID:9108252

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