1aok

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[[Image:1aok.gif|left|200px]]
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{{STRUCTURE_1aok| PDB=1aok | SCENE= }}
{{STRUCTURE_1aok| PDB=1aok | SCENE= }}
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'''VIPOXIN COMPLEX'''
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===VIPOXIN COMPLEX===
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==Overview==
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Vipoxin is the main toxic component in the venom of the Bulgarian snake Vipera ammodytes meridionalis, the most toxic snake in Europe. Vipoxin is a complex between a toxic phospholipase A2 (PLA2) and a non-toxic protein inhibitor. The structure is of genetic interest due to the high degree of sequence homology (62%) between the two functionally different components. The structure shows that the formation of the complex in vipoxin is significantly different to that seen in many known structures of phospholipases and contradicts the assumptions made in earlier studies. The modulation of PLA2 activity is of great pharmacological interest, and the present structure will be a model for structure-based drug design.
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The line below this paragraph, {{ABSTRACT_PUBMED_9276469}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9276469 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9276469}}
==About this Structure==
==About this Structure==
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[[Category: Snake-venom]]
[[Category: Snake-venom]]
[[Category: Vipoxin]]
[[Category: Vipoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:17:52 2008''

Revision as of 14:17, 30 June 2008

Image:1aok.png

Template:STRUCTURE 1aok

VIPOXIN COMPLEX

Template:ABSTRACT PUBMED 9276469

About this Structure

1AOK is a Protein complex structure of sequences from Vipera ammodytes meridionalis. Full crystallographic information is available from OCA.

Reference

Crystal structure of vipoxin at 2.0 A: an example of regulation of a toxic function generated by molecular evolution., Perbandt M, Wilson JC, Eschenburg S, Mancheva I, Aleksiev B, Genov N, Willingmann P, Weber W, Singh TP, Betzel C, FEBS Lett. 1997 Aug 4;412(3):573-7. PMID:9276469

Page seeded by OCA on Mon Jun 30 17:17:52 2008

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