1aoj

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{{STRUCTURE_1aoj| PDB=1aoj | SCENE= }}
{{STRUCTURE_1aoj| PDB=1aoj | SCENE= }}
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'''THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER'''
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===THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER===
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==Overview==
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SH3 domains are structurally well-characterized as monomeric modular units of protein structure that mediate protein-protein recognition in numerous signal transduction proteins. The X-ray crystallographic structure of the Eps8 SH3 domain reveals a novel variation of the canonical SH3 fold: the SH3 domain from Eps8 is a dimer formed by strand interchange. In addition, co-immunoprecipitation experiments show that intact Eps8 is multimeric in vivo. Hence, the SH3 domain of Eps8 may represent a dimerization motif.
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(as it appears on PubMed at http://www.pubmed.gov), where 9303002 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9303002}}
==About this Structure==
==About this Structure==
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[[Category: Sh3 domain]]
[[Category: Sh3 domain]]
[[Category: Signal transduction]]
[[Category: Signal transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:31:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:17:52 2008''

Revision as of 14:17, 30 June 2008

Template:STRUCTURE 1aoj

THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER

Template:ABSTRACT PUBMED 9303002

About this Structure

1AOJ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

The SH3 domain of Eps8 exists as a novel intertwined dimer., Kishan KV, Scita G, Wong WT, Di Fiore PP, Newcomer ME, Nat Struct Biol. 1997 Sep;4(9):739-43. PMID:9303002

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