1aol

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[[Image:1aol.gif|left|200px]]
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{{Seed}}
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[[Image:1aol.png|left|200px]]
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{{STRUCTURE_1aol| PDB=1aol | SCENE= }}
{{STRUCTURE_1aol| PDB=1aol | SCENE= }}
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'''FRIEND MURINE LEUKEMIA VIRUS RECEPTOR-BINDING DOMAIN'''
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===FRIEND MURINE LEUKEMIA VIRUS RECEPTOR-BINDING DOMAIN===
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==Overview==
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An essential step in retrovirus infection is the binding of the virus to its receptor on a target cell. The structure of the receptor-binding domain of the envelope glycoprotein from Friend murine leukemia virus was determined to 2.0 angstrom resolution by x-ray crystallography. The core of the domain is an antiparallel beta sandwich, with two interstrand loops forming a helical subdomain atop the sandwich. The residues in the helical region, but not in the beta sandwich, are highly variable among mammalian C-type retroviruses with distinct tropisms, indicating that the helical subdomain determines the receptor specificity of the virus.
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(as it appears on PubMed at http://www.pubmed.gov), where 9287219 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9287219}}
==About this Structure==
==About this Structure==
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[[Category: Retrovirus]]
[[Category: Retrovirus]]
[[Category: Viral glycoprotein]]
[[Category: Viral glycoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:31:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:17:54 2008''

Revision as of 14:18, 30 June 2008

Image:1aol.png

Template:STRUCTURE 1aol

FRIEND MURINE LEUKEMIA VIRUS RECEPTOR-BINDING DOMAIN

Template:ABSTRACT PUBMED 9287219

About this Structure

1AOL is a Single protein structure of sequence from Friend murine leukemia virus. Full crystallographic information is available from OCA.

Reference

Structure of a murine leukemia virus receptor-binding glycoprotein at 2.0 angstrom resolution., Fass D, Davey RA, Hamson CA, Kim PS, Cunningham JM, Berger JM, Science. 1997 Sep 12;277(5332):1662-6. PMID:9287219

Page seeded by OCA on Mon Jun 30 17:17:54 2008

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