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1ap8

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[[Image:1ap8.gif|left|200px]]
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{{Seed}}
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[[Image:1ap8.png|left|200px]]
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{{STRUCTURE_1ap8| PDB=1ap8 | SCENE= }}
{{STRUCTURE_1ap8| PDB=1ap8 | SCENE= }}
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'''TRANSLATION INITIATION FACTOR EIF4E IN COMPLEX WITH M7GDP, NMR, 20 STRUCTURES'''
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===TRANSLATION INITIATION FACTOR EIF4E IN COMPLEX WITH M7GDP, NMR, 20 STRUCTURES===
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==Overview==
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eIF4E, the mRNA cap binding protein, is a master switch that controls eukaryotic translation. To be active, it must bind eIF4G and form the eIF4F complex, which also contains eIF4A. Translation is downregulated by association of eIF4E with 4E-BP, which occupies the eIF4G binding site. Signalling events acting on 4E-BP cause it to dissociate from eIF4E, and eIF4E is then free to bind eIF4G to form the active eIF4F complex. We have solved the structure of the yeast eIF4E/m7Gpp complex in a CHAPS micelle. We determined the position of the second nucleotide in a complex with m7GpppA, and identified the 4E-BP binding site. eIF4E has a curved eight-stranded antiparallel beta-sheet, decorated with three helices on the convex face and three smaller helices inserted in connecting loops. The m7G of the cap is intercalated into a stack of tryptophans in the concave face. The 4E-BP binding site is located in a region encompassing one edge of the beta-sheet, the adjacent helix a2 and several regions of non-regular secondary structure. It is adjacent to, but does not overlap the cap-binding site.
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{{ABSTRACT_PUBMED_9302999}}
==About this Structure==
==About this Structure==
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1AP8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AP8 OCA].
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1AP8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AP8 OCA].
==Reference==
==Reference==
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[[Category: Rna cap]]
[[Category: Rna cap]]
[[Category: Translation initiation factor]]
[[Category: Translation initiation factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:32:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:20:32 2008''

Revision as of 14:20, 30 June 2008

Image:1ap8.png

Template:STRUCTURE 1ap8

TRANSLATION INITIATION FACTOR EIF4E IN COMPLEX WITH M7GDP, NMR, 20 STRUCTURES

Template:ABSTRACT PUBMED 9302999

About this Structure

1AP8 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full experimental information is available from OCA.

Reference

Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein., Matsuo H, Li H, McGuire AM, Fletcher CM, Gingras AC, Sonenberg N, Wagner G, Nat Struct Biol. 1997 Sep;4(9):717-24. PMID:9302999

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