1aqc

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[[Image:1aqc.gif|left|200px]]
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{{STRUCTURE_1aqc| PDB=1aqc | SCENE= }}
{{STRUCTURE_1aqc| PDB=1aqc | SCENE= }}
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'''X11 PTB DOMAIN-10MER PEPTIDE COMPLEX'''
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===X11 PTB DOMAIN-10MER PEPTIDE COMPLEX===
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==Overview==
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The crystal structure of the phosphotyrosine-binding domain (PTB) of the X11 protein has been determined, in complex with unphosphorylated peptides corresponding to a region of beta-amyloid precursor protein (betaAPP) that is required for receptor internalization. The mode of binding to X11 of the unphosphorylated peptides, which contain an NPxY motif, resembles that of phosphorylated peptides bound to the Shc and IRS-1 PTB domains. Eight peptide residues make specific contacts with the X11 PTB domain, and they collectively achieve high affinity (KD = 0.32 microM) and specificity. These results suggest that, in contrast to the SH2 domains, the PTB domains are primarily peptide-binding domains that have, in some cases, acquired specificity for phosphorylated tyrosines.
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(as it appears on PubMed at http://www.pubmed.gov), where 9321393 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9321393}}
==About this Structure==
==About this Structure==
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[[Category: Peptide binding module]]
[[Category: Peptide binding module]]
[[Category: Ptb domain]]
[[Category: Ptb domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:34:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:24:25 2008''

Revision as of 14:24, 30 June 2008

Image:1aqc.png

Template:STRUCTURE 1aqc

X11 PTB DOMAIN-10MER PEPTIDE COMPLEX

Template:ABSTRACT PUBMED 9321393

About this Structure

1AQC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain., Zhang Z, Lee CH, Mandiyan V, Borg JP, Margolis B, Schlessinger J, Kuriyan J, EMBO J. 1997 Oct 15;16(20):6141-50. PMID:9321393

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