1aqg

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[[Image:1aqg.jpg|left|200px]]
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{{STRUCTURE_1aqg| PDB=1aqg | SCENE= }}
{{STRUCTURE_1aqg| PDB=1aqg | SCENE= }}
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'''NMR STRUCTURE OF THE RHODOPSIN-BOUND C-TERMINAL PEPTIDE OF THE TRANSDUCIN ALPHA-SUBUNIT, 20 STRUCTURES'''
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===NMR STRUCTURE OF THE RHODOPSIN-BOUND C-TERMINAL PEPTIDE OF THE TRANSDUCIN ALPHA-SUBUNIT, 20 STRUCTURES===
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==Overview==
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A large superfamily of transmembrane receptors control cellular responses to diverse extracellular signals by catalyzing activation of specific types of heterotrimeric GTP-binding proteins. How these receptors recognize and promote nucleotide exchange on G protein alpha subunits to initiate signal amplification is unknown. The three-dimensional structure of the transducin (Gt) alpha subunit C-terminal undecapeptide Gtalpha(340-350) IKENLKDCGLF was determined by transferred nuclear Overhauser effect spectroscopy while it was bound to photoexcited rhodopsin. Light activation of rhodopsin causes a dramatic shift from a disordered conformation of Gtalpha(340-350) to a binding motif with a helical turn followed by an open reverse turn centered at Gly-348, a helix-terminating C capping motif of an alphaL type. Docking of the NMR structure to the GDP-bound x-ray structure of Gt reveals that photoexcited rhodopsin promotes the formation of a continuous helix over residues 325-346 terminated by the C-terminal helical cap with a unique cluster of crucial hydrophobic side chains. A molecular mechanism by which activated receptors can control G proteins through reversible conformational changes at the receptor-G protein interface is demonstrated.
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The line below this paragraph, {{ABSTRACT_PUBMED_9539726}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9539726 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9539726}}
==About this Structure==
==About this Structure==
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1AQG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQG OCA].
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1AQG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQG OCA].
==Reference==
==Reference==
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[[Category: Transducer]]
[[Category: Transducer]]
[[Category: Transducin]]
[[Category: Transducin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:35:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:24:44 2008''

Revision as of 14:24, 30 June 2008

Image:1aqg.png

Template:STRUCTURE 1aqg

NMR STRUCTURE OF THE RHODOPSIN-BOUND C-TERMINAL PEPTIDE OF THE TRANSDUCIN ALPHA-SUBUNIT, 20 STRUCTURES

Template:ABSTRACT PUBMED 9539726

About this Structure

1AQG is a Single protein structure of sequence from Bos taurus. Full experimental information is available from OCA.

Reference

Light-activated rhodopsin induces structural binding motif in G protein alpha subunit., Kisselev OG, Kao J, Ponder JW, Fann YC, Gautam N, Marshall GR, Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4270-5. PMID:9539726

Page seeded by OCA on Mon Jun 30 17:24:44 2008

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