1aqo

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[[Image:1aqo.gif|left|200px]]
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{{Seed}}
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[[Image:1aqo.png|left|200px]]
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{{STRUCTURE_1aqo| PDB=1aqo | SCENE= }}
{{STRUCTURE_1aqo| PDB=1aqo | SCENE= }}
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'''IRON RESPONSIVE ELEMENT RNA HAIRPIN, NMR, 15 STRUCTURES'''
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===IRON RESPONSIVE ELEMENT RNA HAIRPIN, NMR, 15 STRUCTURES===
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==Overview==
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The iron responsive element (IRE) is a approximately 30 nucleotide RNA hairpin that is located in the 5' untranslated region of all ferritin mRNAs and in the 3' untranslated region of all transferrin receptor mRNAs. The IREs are bound by two related IRE-binding proteins (IRPs) which help control intracellular levels of iron by regulating the expression of both ferritin and transferrin receptor genes. Multi-dimensional NMR and computational approaches were used to study the structure and dynamics of the IRE RNA in solution. The NMR data are consistent with formation of A-form helical stem regions, a one-base internal bulge and a Watson-Crick C.G base-pair between the first and fifth nucleotides in the loop. A superposition of refined structures indicates that the conserved C in the internal bulge, and three residues in the six-nucleotide hairpin loop are quite dynamic in this RNA. The structural roles of the stems, the loop and the bulge in the function of the IRE RNA and in possible interactions with the iron regulatory protein are discussed.
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The line below this paragraph, {{ABSTRACT_PUBMED_9398517}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9398517 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9398517}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQO OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQO OCA].
==Reference==
==Reference==
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[[Category: Rna]]
[[Category: Rna]]
[[Category: Translational regulation]]
[[Category: Translational regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:35:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:25:32 2008''

Revision as of 14:25, 30 June 2008

Image:1aqo.png

Template:STRUCTURE 1aqo

IRON RESPONSIVE ELEMENT RNA HAIRPIN, NMR, 15 STRUCTURES

Template:ABSTRACT PUBMED 9398517

About this Structure

Full experimental information is available from OCA.

Reference

Structure and dynamics of the iron responsive element RNA: implications for binding of the RNA by iron regulatory binding proteins., Addess KJ, Basilion JP, Klausner RD, Rouault TA, Pardi A, J Mol Biol. 1997 Nov 21;274(1):72-83. PMID:9398517

Page seeded by OCA on Mon Jun 30 17:25:32 2008

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