1aqp

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{{STRUCTURE_1aqp| PDB=1aqp | SCENE= }}
{{STRUCTURE_1aqp| PDB=1aqp | SCENE= }}
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'''RIBONUCLEASE A COPPER COMPLEX'''
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===RIBONUCLEASE A COPPER COMPLEX===
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==Overview==
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We report the crystal structures of the copper and nickel complexes of RNase A. The overall topology of these two complexes is similar to that of other RNase A structures. However, there are significant differences in the mode of binding of copper and nickel. There are two copper ions per molecule of the protein, but there is only one nickel ion per molecule of the protein. Significant changes occur in the interprotein interactions as a result of differences in the coordinating groups at the common binding site around His-105. Consequently, the copper- and nickel-ion-bound dimers of RNase A act as nucleation sites for generating different crystal lattices for the two complexes. A second copper ion is present at an active site residue His-119 for which all the ligands are from one molecule of the protein. At this second site, His-119 adopts an inactive conformation (B) induced by the copper. We have identified a novel copper binding motif involving the alpha-amino group and the N-terminal residues.
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(as it appears on PubMed at http://www.pubmed.gov), where 9275172 is the PubMed ID number.
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==About this Structure==
==About this Structure==
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Ramasubbu, N.]]
[[Category: Ramasubbu, N.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:35:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:25:41 2008''

Revision as of 14:25, 30 June 2008

Image:1aqp.png

Template:STRUCTURE 1aqp

RIBONUCLEASE A COPPER COMPLEX

Template:ABSTRACT PUBMED 9275172

About this Structure

1AQP is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Crystal structures of the copper and nickel complexes of RNase A: metal-induced interprotein interactions and identification of a novel copper binding motif., Balakrishnan R, Ramasubbu N, Varughese KI, Parthasarathy R, Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9620-5. PMID:9275172

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