1aqv

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[[Image:1aqv.gif|left|200px]]
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{{STRUCTURE_1aqv| PDB=1aqv | SCENE= }}
{{STRUCTURE_1aqv| PDB=1aqv | SCENE= }}
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'''GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH P-BROMOBENZYLGLUTATHIONE'''
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===GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH P-BROMOBENZYLGLUTATHIONE===
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==Overview==
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The three-dimensional structure of human class pi glutathione S-transferase from placenta (hGSTP1-1), a homodimeric enzyme, has been solved by Patterson search methods and refined at 2.8 A resolution to a final crystallographic R-factor of 19.6% (8.0 to 2.8 A resolution). Subunit folding topology, subunit overall structure and subunit association closely resembles the structure of porcine class pi glutathione S-transferase. The binding site of a competitive inhibitor, S-hexylglutathione, is analyzed and the locations of the binding regions for glutathione (G-site) and electrophilic substrates (H-site) are determined. The specific interactions between protein and the inhibitor's glutathione peptide are the same as those observed between glutathione sulfonate and the porcine isozyme. The H-site is located adjacent to the G-site, with the hexyl moiety lying above a segment (residues 8 to 10) connecting strand beta 1 and helix alpha A where it is in hydrophobic contact with Tyr7, Phe8, Val10, Val35 and Tyr106. Catalytic models are discussed on the basis of the molecular structure.
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(as it appears on PubMed at http://www.pubmed.gov), where 1522586 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1522586}}
==About this Structure==
==About this Structure==
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[[Category: Reuter, W.]]
[[Category: Reuter, W.]]
[[Category: Class pi]]
[[Category: Class pi]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:36:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:26:06 2008''

Revision as of 14:26, 30 June 2008

Image:1aqv.png

Template:STRUCTURE 1aqv

GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH P-BROMOBENZYLGLUTATHIONE

Template:ABSTRACT PUBMED 1522586

About this Structure

1AQV is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of class pi glutathione S-transferase from human placenta in complex with S-hexylglutathione at 2.8 A resolution., Reinemer P, Dirr HW, Ladenstein R, Huber R, Lo Bello M, Federici G, Parker MW, J Mol Biol. 1992 Sep 5;227(1):214-26. PMID:1522586

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