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1as4

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{{STRUCTURE_1as4| PDB=1as4 | SCENE= }}
{{STRUCTURE_1as4| PDB=1as4 | SCENE= }}
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'''CLEAVED ANTICHYMOTRYPSIN A349R'''
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===CLEAVED ANTICHYMOTRYPSIN A349R===
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==Overview==
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Expressed in a kinetically trapped folding state, a serpin couples the thermodynamic driving force of a massive beta-sheet rearrangement to the inhibition of a target protease. Hence, the serpin-protease interaction is the premier example of a "spring-loaded" protein-protein interaction. Amino acid substitutions in the hinge region of a serpin reactive loop can weaken the molecular spring, which converts the serpin from an inhibitor into a substrate. To probe the molecular basis of this conversion, we report the crystal structure of A349R antichymotrypsin in the reactive loop cleaved state at 2.1 A resolution. This amino acid substitution does not block the beta-sheet rearrangement despite the burial of R349 in the hydrophobic core of the cleaved serpin along with a salt-linked acetate ion. The inhibitory activity of this serpin variant is not obliterated; remarkably, its inhibitory properties are anion-dependent due to the creation of an anion-binding cavity in the cleaved serpin.
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(as it appears on PubMed at http://www.pubmed.gov), where 9521649 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9521649}}
==Disease==
==Disease==
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[[Category: Serine protease inhibitor]]
[[Category: Serine protease inhibitor]]
[[Category: Serpin]]
[[Category: Serpin]]
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Revision as of 14:30, 30 June 2008

Image:1as4.png

Template:STRUCTURE 1as4

Contents

CLEAVED ANTICHYMOTRYPSIN A349R

Template:ABSTRACT PUBMED 9521649

Disease

Known disease associated with this structure: Alpha-1-antichymotrypsin deficiency OMIM:[107280], Cerebrovascular disease, occlusive OMIM:[107280]

About this Structure

1AS4 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Engineering an anion-binding cavity in antichymotrypsin modulates the "spring-loaded" serpin-protease interaction., Lukacs CM, Rubin H, Christianson DW, Biochemistry. 1998 Mar 10;37(10):3297-304. PMID:9521649

Page seeded by OCA on Mon Jun 30 17:30:06 2008

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