1at0

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{{STRUCTURE_1at0| PDB=1at0 | SCENE= }}
{{STRUCTURE_1at0| PDB=1at0 | SCENE= }}
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'''17-KDA FRAGMENT OF HEDGEHOG C-TERMINAL AUTOPROCESSING DOMAIN'''
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===17-KDA FRAGMENT OF HEDGEHOG C-TERMINAL AUTOPROCESSING DOMAIN===
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==Overview==
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The approximately 25 kDa carboxy-terminal domain of Drosophila Hedgehog protein (Hh-C) possesses an autoprocessing activity that results in an intramolecular cleavage of full-length Hedgehog protein and covalent attachment of a cholesterol moiety to the newly generated amino-terminal fragment. We have identified a 17 kDa fragment of Hh-C (Hh-C17) active in the initiation of autoprocessing and report here its crystal structure. The Hh-C17 structure comprises two homologous subdomains that appear to have arisen from tandem duplication of a primordial gene. Residues in the Hh-C17 active site have been identified, and their role in Hedgehog autoprocessing probed by site-directed mutagenesis. Aspects of sequence, structure, and reaction mechanism are conserved between Hh-C17 and the self-splicing regions of inteins, permitting reconstruction of a plausible evolutionary history of Hh-C and the inteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 9335337 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9335337}}
==About this Structure==
==About this Structure==
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[[Category: Cholesterol transfer]]
[[Category: Cholesterol transfer]]
[[Category: Developmental signaling molecule]]
[[Category: Developmental signaling molecule]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:39:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:32:39 2008''

Revision as of 14:32, 30 June 2008

Image:1at0.png

Template:STRUCTURE 1at0

17-KDA FRAGMENT OF HEDGEHOG C-TERMINAL AUTOPROCESSING DOMAIN

Template:ABSTRACT PUBMED 9335337

About this Structure

1AT0 is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Crystal structure of a Hedgehog autoprocessing domain: homology between Hedgehog and self-splicing proteins., Hall TM, Porter JA, Young KE, Koonin EV, Beachy PA, Leahy DJ, Cell. 1997 Oct 3;91(1):85-97. PMID:9335337

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