1at3

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{{STRUCTURE_1at3| PDB=1at3 | SCENE= }}
{{STRUCTURE_1at3| PDB=1at3 | SCENE= }}
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'''HERPES SIMPLEX VIRUS TYPE II PROTEASE'''
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===HERPES SIMPLEX VIRUS TYPE II PROTEASE===
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==Overview==
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Human herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are responsible for herpes labialis (cold sores) and genital herpes, respectively. They encode a serine protease that is required for viral replication, and represent a viable target for therapeutic intervention. Here, we report the crystal structures of HSV-1 and HSV-2 proteases, the latter in the presence and absence of the covalently bound transition state analog inhibitor diisopropyl phosphate (DIP). The HSV-1 and HSV-2 protease structures show a fold that is neither like chymotrypsin nor like subtilisin, and has been seen only in the recently determined cytomegalovirus (CMV) and varicella-zoster virus (VZV) protease structures. HSV-1 and HSV-2 proteases share high sequence homology and have almost identical three-dimensional structures. However, structural differences are observed with the less homologous CMV protease, offering a structural basis for herpes virus protease ligand specificity. The bound inhibitor identifies the oxyanion hole of these enzymes and defines the active site cavity.
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{{ABSTRACT_PUBMED_9369473}}
==About this Structure==
==About this Structure==
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[[Category: Serine protease]]
[[Category: Serine protease]]
[[Category: Viral protease]]
[[Category: Viral protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:39:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:32:51 2008''

Revision as of 14:32, 30 June 2008

Image:1at3.png

Template:STRUCTURE 1at3

HERPES SIMPLEX VIRUS TYPE II PROTEASE

Template:ABSTRACT PUBMED 9369473

About this Structure

1AT3 is a Single protein structure of sequence from Human herpesvirus 2. Full crystallographic information is available from OCA.

Reference

Active site cavity of herpesvirus proteases revealed by the crystal structure of herpes simplex virus protease/inhibitor complex., Hoog SS, Smith WW, Qiu X, Janson CA, Hellmig B, McQueney MS, O'Donnell K, O'Shannessy D, DiLella AG, Debouck C, Abdel-Meguid SS, Biochemistry. 1997 Nov 18;36(46):14023-9. PMID:9369473

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