1au1

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[[Image:1au1.gif|left|200px]]
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{{Seed}}
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[[Image:1au1.png|left|200px]]
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{{STRUCTURE_1au1| PDB=1au1 | SCENE= }}
{{STRUCTURE_1au1| PDB=1au1 | SCENE= }}
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'''HUMAN INTERFERON-BETA CRYSTAL STRUCTURE'''
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===HUMAN INTERFERON-BETA CRYSTAL STRUCTURE===
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==Overview==
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Type I interferons (IFNs) are helical cytokines that have diverse biological activities despite the fact that they appear to interact with the same receptor system. To achieve a better understanding of the structural basis for the different activities of alpha and beta IFNs, we have determined the crystal structure of glycosylated human IFN-beta at 2.2-A resolution by molecular replacement. The molecule adopts a fold similar to that of the previously determined structures of murine IFN-beta and human IFN-alpha2b but displays several distinct structural features. Like human IFN-alpha2b, human IFN-beta contains a zinc-binding site at the interface of the two molecules in the asymmetric unit, raising the question of functional relevance for IFN-beta dimers. However, unlike the human IFN-alpha2b dimer, in which homologous surfaces form the interface, human IFN-beta dimerizes with contact surfaces from opposite sides of the molecule. The relevance of the structure to the effects of point mutations in IFN-beta at specific exposed residues is discussed. A potential role of ligand-ligand interactions in the conformational assembly of IFN receptor components is discussed.
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The line below this paragraph, {{ABSTRACT_PUBMED_9342320}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9342320 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9342320}}
==About this Structure==
==About this Structure==
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[[Category: Immune system]]
[[Category: Immune system]]
[[Category: Interferon]]
[[Category: Interferon]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:41:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:35:28 2008''

Revision as of 14:35, 30 June 2008

Image:1au1.png

Template:STRUCTURE 1au1

HUMAN INTERFERON-BETA CRYSTAL STRUCTURE

Template:ABSTRACT PUBMED 9342320

About this Structure

1AU1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of human interferon beta at 2.2-A resolution., Karpusas M, Nolte M, Benton CB, Meier W, Lipscomb WN, Goelz S, Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):11813-8. PMID:9342320

Page seeded by OCA on Mon Jun 30 17:35:28 2008

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