1au6

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[[Image:1au6.gif|left|200px]]
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{{Seed}}
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[[Image:1au6.png|left|200px]]
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{{STRUCTURE_1au6| PDB=1au6 | SCENE= }}
{{STRUCTURE_1au6| PDB=1au6 | SCENE= }}
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'''SOLUTION STRUCTURE OF DNA D(CATGCATG) INTERSTRAND-CROSSLINKED BY BISPLATIN COMPOUND (1,1/T,T), NMR, MINIMIZED AVERAGE STRUCTURE'''
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===SOLUTION STRUCTURE OF DNA D(CATGCATG) INTERSTRAND-CROSSLINKED BY BISPLATIN COMPOUND (1,1/T,T), NMR, MINIMIZED AVERAGE STRUCTURE===
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==Overview==
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The bifunctional platinum compound, [(trans-PtCI(NH)3)2)2(H2N(CH2)4NH2)]2+, forms a stable adduct with the self-complementary DNA oligomer CATGCATG, with the two platinum atoms coordinated at the N7 positions of the two symmetrical G4 nucleotides. The NMR-derived structure shows that the DNA octamer forms a novel hairpin structure with the platinated G4 residue adopting a syn conformation and the guanine base in the minor groove. Two such hairpins stack end-over-end and are linked together by the butanediamine tether to form a dumbbell structure. Such unusual structural distortion is different from that of the anticancer drug cisplatin-DNA adduct and may provide clues to explain the distinct biological activities of the two compounds.
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The line below this paragraph, {{ABSTRACT_PUBMED_7664126}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7664126 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7664126}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AU6 OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AU6 OCA].
==Reference==
==Reference==
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[[Category: Dumbbell structure]]
[[Category: Dumbbell structure]]
[[Category: Interstrand crosslink]]
[[Category: Interstrand crosslink]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:41:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:35:59 2008''

Revision as of 14:36, 30 June 2008

Image:1au6.png

Template:STRUCTURE 1au6

SOLUTION STRUCTURE OF DNA D(CATGCATG) INTERSTRAND-CROSSLINKED BY BISPLATIN COMPOUND (1,1/T,T), NMR, MINIMIZED AVERAGE STRUCTURE

Template:ABSTRACT PUBMED 7664126

About this Structure

Full experimental information is available from OCA.

Reference

A novel DNA structure induced by the anticancer bisplatinum compound crosslinked to a GpC site in DNA., Yang D, van Boom SS, Reedijk J, van Boom JH, Farrell N, Wang AH, Nat Struct Biol. 1995 Jul;2(7):577-8. PMID:7664126

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