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| - | [[Image:1avb.jpg|left|200px]] | + | {{Seed}} |
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| | {{STRUCTURE_1avb| PDB=1avb | SCENE= }} | | {{STRUCTURE_1avb| PDB=1avb | SCENE= }} |
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| - | '''ARCELIN-1 FROM PHASEOLUS VULGARIS L'''
| + | ===ARCELIN-1 FROM PHASEOLUS VULGARIS L=== |
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| - | ==Overview==
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| - | Arcelin-1 is a glycoprotein from kidney beans (Phaseolus vulgaris) which displays insecticidal properties and protects the seeds from predation by larvae of various bruchids. This lectin-like protein is devoid of monosaccharide binding properties and belongs to the phytohemagglutinin protein family. The x-ray structure determination at 1.9-A resolution of native arcelin-1 dimers, which correspond to the functional state of the protein in solution, was solved using multiple isomorphous replacement and refined to a crystallographic R factor of 0.208. The three glycosylation sites on each monomer are all covalently modified. One of these oligosaccharide chains provides interactions with protein atoms at the dimer interface, and another one may act by preventing the formation of higher oligomeric species in the arcelin variants. The dimeric structure and the severe alteration of the monosaccharide binding site in arcelin-1 correlate with the hemagglutinating properties of the protein, which are unaffected by simple sugars and sugar derivatives. Sequence analysis and structure comparisons of arcelin-1 with the other insecticidal proteins from kidney beans, arcelin-5, and alpha-amylase inhibitor and with legume lectins, yield insights into the molecular basis of the different biological functions of these proteins.
| + | The line below this paragraph, {{ABSTRACT_PUBMED_9582323}}, adds the Publication Abstract to the page |
| | + | (as it appears on PubMed at http://www.pubmed.gov), where 9582323 is the PubMed ID number. |
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| | + | {{ABSTRACT_PUBMED_9582323}} |
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| | ==About this Structure== | | ==About this Structure== |
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| | [[Category: Lectin-like glycoprotein]] | | [[Category: Lectin-like glycoprotein]] |
| | [[Category: Plant defense]] | | [[Category: Plant defense]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:44:15 2008'' | + | |
| | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:40:01 2008'' |
Revision as of 14:40, 30 June 2008
Template:STRUCTURE 1avb
ARCELIN-1 FROM PHASEOLUS VULGARIS L
Template:ABSTRACT PUBMED 9582323
About this Structure
1AVB is a Single protein structure of sequence from Phaseolus vulgaris. Full crystallographic information is available from OCA.
Reference
Crystal structure of the arcelin-1 dimer from Phaseolus vulgaris at 1.9-A resolution., Mourey L, Pedelacq JD, Birck C, Fabre C, Rouge P, Samama JP, J Biol Chem. 1998 May 22;273(21):12914-22. PMID:9582323
Page seeded by OCA on Mon Jun 30 17:40:01 2008
