1awi

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[[Image:1awi.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1awi| PDB=1awi | SCENE= }}
{{STRUCTURE_1awi| PDB=1awi | SCENE= }}
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'''HUMAN PLATELET PROFILIN COMPLEXED WITH THE L-PRO10 PEPTIDE'''
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===HUMAN PLATELET PROFILIN COMPLEXED WITH THE L-PRO10 PEPTIDE===
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==Overview==
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Profilin, a ubiquitous low molecular weight (13,000-15,000 M(r)) actin binding protein, regulates the formation of F-actin structures in vivo, and is localized to specific cellular regions through interaction with proline-rich sequences. Here we report the 2.2 A X-ray structure of the complex between human platelet profilin (HPP) and a decamer of L-proline (L-Pro10). The L-Pro10 peptide adopts a left-handed type II poly-L-proline helix (PPII) and binds to a highly conserved patch of aromatic amino acids on the surface of profilin. The peptide and actin binding sites reside on orthogonal surfaces, and L-Pro10 binding does not result in a conformational rearrangement of HPP. This structure suggests a mechanism for the localization of profilin and its actin-related activities to sites of actin filament assembly in vivo.
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The line below this paragraph, {{ABSTRACT_PUBMED_9360613}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9360613 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9360613}}
==About this Structure==
==About this Structure==
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[[Category: Poly-l-proline]]
[[Category: Poly-l-proline]]
[[Category: Profilin]]
[[Category: Profilin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:46:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:45:06 2008''

Revision as of 14:45, 30 June 2008

Image:1awi.png

Template:STRUCTURE 1awi

HUMAN PLATELET PROFILIN COMPLEXED WITH THE L-PRO10 PEPTIDE

Template:ABSTRACT PUBMED 9360613

About this Structure

1AWI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the profilin-poly-L-proline complex involved in morphogenesis and cytoskeletal regulation., Mahoney NM, Janmey PA, Almo SC, Nat Struct Biol. 1997 Nov;4(11):953-60. PMID:9360613

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