1azd

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[[Image:1azd.jpg|left|200px]]
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{{Seed}}
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[[Image:1azd.png|left|200px]]
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{{STRUCTURE_1azd| PDB=1azd | SCENE= }}
{{STRUCTURE_1azd| PDB=1azd | SCENE= }}
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'''CONCANAVALIN FROM CANAVALIA BRASILIENSIS'''
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===CONCANAVALIN FROM CANAVALIA BRASILIENSIS===
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==Overview==
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Canavalia brasiliensis lectin was isolated from the seeds of a Brazilian autochthonous Leguminosae plant. Despite extensive amino acid sequence similarity with Concanavalin A, C. brasiliensis lectin exerts in vitro and in vivo cellular effects that are markedly different from those displayed by Concanavalin A. We have solved the crystal structure of the C. brasiliensis lectin at 3.0 A resolution. The three-dimensional structure of the lectin monomer can be superimposed onto that of Concanavalin A with a root-mean-square deviation for all C alpha atoms of 0.65 A. However, this parameter is 0.84 and 1.62 A when the C. brasiliensis lectin dimer and tetramer, respectively, are compared with the same structures of Concanavalin A. We suggest that these differences in quaternary structure may account for the different biological properties of these two highly related Leguminosae lectins.
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(as it appears on PubMed at http://www.pubmed.gov), where 9094437 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9094437}}
==About this Structure==
==About this Structure==
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[[Category: Sanz-Aparicio, J.]]
[[Category: Sanz-Aparicio, J.]]
[[Category: Legume lectin]]
[[Category: Legume lectin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:54:29 2008''

Revision as of 14:54, 30 June 2008

Image:1azd.png

Template:STRUCTURE 1azd

CONCANAVALIN FROM CANAVALIA BRASILIENSIS

Template:ABSTRACT PUBMED 9094437

About this Structure

1AZD is a Single protein structure of sequence from Canavalia brasiliensis. Full crystallographic information is available from OCA.

Reference

The crystal structure of Canavalia brasiliensis lectin suggests a correlation between its quaternary conformation and its distinct biological properties from Concanavalin A., Sanz-Aparicio J, Hermoso J, Grangeiro TB, Calvete JJ, Cavada BS, FEBS Lett. 1997 Mar 17;405(1):114-8. PMID:9094437

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