1azp

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[[Image:1azp.gif|left|200px]]
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{{STRUCTURE_1azp| PDB=1azp | SCENE= }}
{{STRUCTURE_1azp| PDB=1azp | SCENE= }}
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'''HYPERTHERMOPHILE CHROMOSOMAL PROTEIN SAC7D BOUND WITH KINKED DNA DUPLEX'''
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===HYPERTHERMOPHILE CHROMOSOMAL PROTEIN SAC7D BOUND WITH KINKED DNA DUPLEX===
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==Overview==
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The proteins Sac7d and Sso7d belong to a class of small chromosomal proteins from the hyperthermophilic archaeon Sulfolobus acidocaldarius and S. solfactaricus, respectively. These proteins are extremely stable to heat, acid and chemical agents. Sac7d binds to DNA without any particular sequence preference and thereby increases its melting temperature by approximately 40 degrees C. We have now solved and refined the crystal structure of Sac7d in complex with two DNA sequences to high resolution. The structures are examples of a nonspecific DNA-binding protein bound to DNA, and reveal that Sac7d binds in the minor groove, causing a sharp kinking of the DNA helix that is more marked than that induced by any sequence-specific DNA-binding proteins. The kink results from the intercalation of specific hydrophobic side chains of Sac7d into the DNA structure, but without causing any significant distortion of the protein structure relative to the uncomplexed protein in solution.
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(as it appears on PubMed at http://www.pubmed.gov), where 9515968 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9515968}}
==About this Structure==
==About this Structure==
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[[Category: Intercalation]]
[[Category: Intercalation]]
[[Category: Minor-groove binding]]
[[Category: Minor-groove binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:53:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:55:45 2008''

Revision as of 14:55, 30 June 2008

Image:1azp.png

Template:STRUCTURE 1azp

HYPERTHERMOPHILE CHROMOSOMAL PROTEIN SAC7D BOUND WITH KINKED DNA DUPLEX

Template:ABSTRACT PUBMED 9515968

About this Structure

1AZP is a Single protein structure of sequence from Sulfolobus acidocaldarius. Full crystallographic information is available from OCA.

Reference

The hyperthermophile chromosomal protein Sac7d sharply kinks DNA., Robinson H, Gao YG, McCrary BS, Edmondson SP, Shriver JW, Wang AH, Nature. 1998 Mar 12;392(6672):202-5. PMID:9515968

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