1b0a

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{{STRUCTURE_1b0a| PDB=1b0a | SCENE= }}
{{STRUCTURE_1b0a| PDB=1b0a | SCENE= }}
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'''5,10, METHYLENE-TETRAHYDROPHOLATE DEHYDROGENASE/CYCLOHYDROLASE FROM E COLI.'''
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===5,10, METHYLENE-TETRAHYDROPHOLATE DEHYDROGENASE/CYCLOHYDROLASE FROM E COLI.===
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==Overview==
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The structure of a bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/cyclohydrolase from Escherichia coli has been determined at 2.5 A resolution in the absence of bound substrates and compared to the NADP-bound structure of the homologous enzyme domains from a trifunctional human synthetase enzyme. Superposition of these structures allows the identification of a highly conserved cluster of basic residues that are appropriately positioned to serve as a binding site for the poly-gamma-glutamyl tail of the tetrahydrofolate substrate. Modeling studies and molecular dynamic simulations of bound methylene-tetrahydrofolate and NADP shows that this binding site would allow interaction of the nicotinamide and pterin rings in the dehydrogenase active site. Comparison of these enzymes also indicates differences between their active sites that might allow the development of inhibitors specific to the bacterial target.
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(as it appears on PubMed at http://www.pubmed.gov), where 10386884 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10386884}}
==About this Structure==
==About this Structure==
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[[Category: Dehydrogenase]]
[[Category: Dehydrogenase]]
[[Category: Folate]]
[[Category: Folate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:54:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:58:13 2008''

Revision as of 14:58, 30 June 2008

Image:1b0a.png

Template:STRUCTURE 1b0a

5,10, METHYLENE-TETRAHYDROPHOLATE DEHYDROGENASE/CYCLOHYDROLASE FROM E COLI.

Template:ABSTRACT PUBMED 10386884

About this Structure

1B0A is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The crystal structure of a bacterial, bifunctional 5,10 methylene-tetrahydrofolate dehydrogenase/cyclohydrolase., Shen BW, Dyer DH, Huang JY, D'Ari L, Rabinowitz J, Stoddard BL, Protein Sci. 1999 Jun;8(6):1342-9. PMID:10386884

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