1b0o

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[[Image:1b0o.gif|left|200px]]
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{{STRUCTURE_1b0o| PDB=1b0o | SCENE= }}
{{STRUCTURE_1b0o| PDB=1b0o | SCENE= }}
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'''BOVINE BETA-LACTOGLOBULIN COMPLEXED WITH PALMITATE, LATTICE Z'''
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===BOVINE BETA-LACTOGLOBULIN COMPLEXED WITH PALMITATE, LATTICE Z===
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==Overview==
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Bovine beta-lactoglobulin (beta-Lg) has been studied extensively in both the isolated and the naturally occurring states. It is a commercially important whey protein of obvious nutritional value but, so far, one that has no clearly identified biological function. In common with many of the other members of the lipocalin family to which it belongs, beta-Lg binds hydrophobic ligands, and it appears possible that there are at least two distinct binding sites per monomer for a variety of ligands. By comparison with other members of the family, there is a probable binding site in the central cavity of the molecule that is formed by the eight antiparallel beta-strands that are typical of the lipocalins. We have now cocrystallized beta-Lg with palmitic acid, and the refined structure (R = 0.204, Rfree = 0.240 for 6,888 reflections to 2.5-A resolution) reveals that the ligand binds in the central cavity in a manner similar to the binding of retinol to the related lipocalin, serum retinol-binding protein. The carboxyl group binds to both Lys-60 and Lys-69 at the entrance to the cavity. The hydrophobic tail stretches in an almost fully extended conformation into the center of the protein. This is the first direct observation of a ligand binding to beta-Lg.
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The line below this paragraph, {{ABSTRACT_PUBMED_9867826}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9867826 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9867826}}
==About this Structure==
==About this Structure==
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[[Category: Milk whey protein]]
[[Category: Milk whey protein]]
[[Category: Palmitate-binding]]
[[Category: Palmitate-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:55:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:59:41 2008''

Revision as of 14:59, 30 June 2008

Image:1b0o.png

Template:STRUCTURE 1b0o

BOVINE BETA-LACTOGLOBULIN COMPLEXED WITH PALMITATE, LATTICE Z

Template:ABSTRACT PUBMED 9867826

About this Structure

1B0O is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

beta-lactoglobulin binds palmitate within its central cavity., Wu SY, Perez MD, Puyol P, Sawyer L, J Biol Chem. 1999 Jan 1;274(1):170-4. PMID:9867826

Page seeded by OCA on Mon Jun 30 17:59:41 2008

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