2jd2
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(New page: 200px<br /> <applet load="2jd2" size="450" color="white" frame="true" align="right" spinBox="true" caption="2jd2, resolution 2.15Å" /> '''X-RAY STRUCTURE OF ...)
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Revision as of 17:36, 29 October 2007
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X-RAY STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, DXR, RV2870C, FROM MYCOBACTERIUM TUBERCULOSIS, IN COMPLEX WITH MANGANESE
Overview
Isopentenyl diphosphate is the precursor of various isoprenoids that are, essential to all living organisms. It is produced by the mevalonate, pathway in humans but by an alternate route in plants, protozoa, and many, bacteria. 1-deoxy-D-xylulose-5-phosphate reductoisomerase catalyzes the, second step of this non-mevalonate pathway, which involves an, NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose, 5-phosphate to form 2-C-methyl-D-erythritol 4-phosphate. The use of, different pathways, combined with the reported essentiality of the enzyme, makes the reductoisomerase a highly promising target for drug design. Here, we present several high resolution structures of the Mycobacterium, tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase, representing, both wild type ... [(full description)]
About this Structure
2JD2 is a [Single protein] structure of sequence from [Mycobacterium tuberculosis] with MN and SO4 as [ligands]. Active as [[1]], with EC number [1.1.1.267]. Full crystallographic information is available from [OCA].
Reference
Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysis., Henriksson LM, Unge T, Carlsson J, Aqvist J, Mowbray SL, Jones TA, J Biol Chem. 2007 Jul 6;282(27):19905-16. Epub 2007 May 9. PMID:17491006
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