1b3j

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[[Image:1b3j.gif|left|200px]]
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{{Seed}}
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[[Image:1b3j.png|left|200px]]
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{{STRUCTURE_1b3j| PDB=1b3j | SCENE= }}
{{STRUCTURE_1b3j| PDB=1b3j | SCENE= }}
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'''STRUCTURE OF THE MHC CLASS I HOMOLOG MIC-A, A GAMMADELTA T CELL LIGAND'''
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===STRUCTURE OF THE MHC CLASS I HOMOLOG MIC-A, A GAMMADELTA T CELL LIGAND===
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==Overview==
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The major histocompatibility complex (MHC) class I homolog MIC-A functions as a stress-inducible antigen that is recognized by a subset of gammadelta T cells independent of beta2-microglobulin and bound peptides. Its crystal structure reveals a dramatically altered MHC class I fold, both in detail and overall domain organization. The only remnant of a peptide-binding groove is a small cavity formed as the result of disordering a large section of one of the groove-defining helices. Loss of beta2-microglobulin binding is due to a restructuring of the interaction interfaces. Structural mapping of sequence variation suggests potential receptor binding sites on the underside of the platform on the side opposite of the surface recognized by alphabeta T cell receptors on MHC class I-peptide complexes.
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The line below this paragraph, {{ABSTRACT_PUBMED_10367903}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10367903 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10367903}}
==About this Structure==
==About this Structure==
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[[Category: Signa immunoglobulin fold]]
[[Category: Signa immunoglobulin fold]]
[[Category: T-cell]]
[[Category: T-cell]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:01:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:09:34 2008''

Revision as of 15:09, 30 June 2008

Image:1b3j.png

Template:STRUCTURE 1b3j

STRUCTURE OF THE MHC CLASS I HOMOLOG MIC-A, A GAMMADELTA T CELL LIGAND

Template:ABSTRACT PUBMED 10367903

About this Structure

1B3J is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the MHC class I homolog MIC-A, a gammadelta T cell ligand., Li P, Willie ST, Bauer S, Morris DL, Spies T, Strong RK, Immunity. 1999 May;10(5):577-84. PMID:10367903

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