This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1b3p

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1b3p.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1b3p.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1b3p| PDB=1b3p | SCENE= }}
{{STRUCTURE_1b3p| PDB=1b3p | SCENE= }}
-
'''5'-D(*GP*GP*AP*GP*GP*AP*T)-3''''
+
===5'-D(*GP*GP*AP*GP*GP*AP*T)-3'===
-
==Overview==
+
<!--
-
BACKGROUND: Triplet repeat sequences are of considerable biological importance as the expansion of such tandem arrays can lead to the onset of a range of human diseases. Such sequences can self-pair via mismatch alignments to form higher order structures that have the potential to cause replication blocks, followed by strand slippage and sequence expansion. The all-purine d(GGA)n triplet repeat sequence is of particular interest because purines can align via G.G, A.A and G.A mismatch formation. RESULTS: We have solved the structure of the uniformly 13C,15N-labeled d(G1-G2-A3-G4-G5-A6-T7) sequence in 10 mM Na+ solution. This sequence adopts a novel twofold-symmetric duplex fold where interlocked V-shaped arrowhead motifs are aligned solely via interstrand G1.G4, G2.G5 and A3.A6 mismatch formation. The tip of the arrowhead motif is centered about the p-A3-p step, and symmetry-related local parallel-stranded duplex domains are formed by the G1-G2-A3 and G4-G5-A6 segments of partner strands. CONCLUSIONS: The purine-rich (GGA)n triplet repeat sequence is dispersed throughout the eukaryotic genome. Several features of the arrowhead duplex motif for the (GGA)2 triplet repeat provide a unique scaffold for molecular recognition. These include the large localized bend in the sugar-phosphate backbones, the segmental parallel-stranded alignment of strands and the exposure of the Watson-Crick edges of several mismatched bases.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10425682}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10425682 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10425682}}
==About this Structure==
==About this Structure==
-
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B3P OCA].
+
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B3P OCA].
==Reference==
==Reference==
Line 32: Line 36:
[[Category: Uniform 13c]]
[[Category: Uniform 13c]]
[[Category: V-shaped backbone]]
[[Category: V-shaped backbone]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:01:29 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:10:25 2008''

Revision as of 15:10, 30 June 2008

Image:1b3p.png

Template:STRUCTURE 1b3p

5'-D(*GP*GP*AP*GP*GP*AP*T)-3'

Template:ABSTRACT PUBMED 10425682

About this Structure

Full experimental information is available from OCA.

Reference

Interlocked mismatch-aligned arrowhead DNA motifs., Kettani A, Bouaziz S, Skripkin E, Majumdar A, Wang W, Jones RA, Patel DJ, Structure. 1999 Jul 15;7(7):803-15. PMID:10425682

Page seeded by OCA on Mon Jun 30 18:10:25 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1b3p"
Personal tools