1b4b

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{{STRUCTURE_1b4b| PDB=1b4b | SCENE= }}
{{STRUCTURE_1b4b| PDB=1b4b | SCENE= }}
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'''STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF THE ARGININE REPRESSOR FROM BACILLUS STEAROTHERMOPHILUS'''
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===STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF THE ARGININE REPRESSOR FROM BACILLUS STEAROTHERMOPHILUS===
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==Overview==
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The arginine repressor (ArgR) is a hexameric DNA-binding protein that plays a multifunctional role in the bacterial cell. Here, we present the 2.5 A structure of apo-ArgR from Bacillus stearothermophilus and the 2.2 A structure of the hexameric ArgR oligomerization domain with bound arginine. This first view of intact ArgR reveals an approximately 32-symmetric hexamer of identical subunits, with six DNA-binding domains surrounding a central oligomeric core. The difference in quaternary organization of subunits in the arginine-bound and apo forms provides a possible explanation for poor operator binding by apo-ArgR and for high affinity binding in the presence of arginine.
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(as it appears on PubMed at http://www.pubmed.gov), where 10331868 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10331868}}
==About this Structure==
==About this Structure==
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[[Category: Oligomerization domain]]
[[Category: Oligomerization domain]]
[[Category: Repressor]]
[[Category: Repressor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:13:09 2008''

Revision as of 15:13, 30 June 2008

Template:STRUCTURE 1b4b

STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF THE ARGININE REPRESSOR FROM BACILLUS STEAROTHERMOPHILUS

Template:ABSTRACT PUBMED 10331868

About this Structure

1B4B is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.

Reference

Structure of the arginine repressor from Bacillus stearothermophilus., Ni J, Sakanyan V, Charlier D, Glansdorff N, Van Duyne GD, Nat Struct Biol. 1999 May;6(5):427-32. PMID:10331868

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