1b4c

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{{STRUCTURE_1b4c| PDB=1b4c | SCENE= }}
{{STRUCTURE_1b4c| PDB=1b4c | SCENE= }}
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'''SOLUTION STRUCTURE OF RAT APO-S100B USING DIPOLAR COUPLINGS'''
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===SOLUTION STRUCTURE OF RAT APO-S100B USING DIPOLAR COUPLINGS===
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==Overview==
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The relative orientations of adjacent structural elements without many well-defined NOE contacts between them are typically poorly defined in NMR structures. For apo-S100B(betabeta) and the structurally homologous protein calcyclin, the solution structures determined by conventional NMR exhibited considerable differences and made it impossible to draw unambiguous conclusions regarding the Ca2+-induced conformational change required for target protein binding. The structure of rat apo-S100B(betabeta) was recalculated using a large number of constraints derived from dipolar couplings that were measured in a dilute liquid crystalline phase. The dipolar couplings orient bond vectors relative to a single-axis system, and thereby remove much of the uncertainty in NOE-based structures. The structure of apo-S100B(betabeta) indicates a minimal change in the first, pseudo-EF-hand Ca2+ binding site, but a large reorientation of helix 3 in the second, classical EF-hand upon Ca2+ binding.
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{{ABSTRACT_PUBMED_10211826}}
==About this Structure==
==About this Structure==
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1B4C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B4C OCA].
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1B4C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B4C OCA].
==Reference==
==Reference==
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[[Category: Solution structure]]
[[Category: Solution structure]]
[[Category: Three-dimensional structure]]
[[Category: Three-dimensional structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:13:31 2008''

Revision as of 15:13, 30 June 2008

Image:1b4c.png

Template:STRUCTURE 1b4c

SOLUTION STRUCTURE OF RAT APO-S100B USING DIPOLAR COUPLINGS

Template:ABSTRACT PUBMED 10211826

About this Structure

1B4C is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

The use of dipolar couplings for determining the solution structure of rat apo-S100B(betabeta)., Drohat AC, Tjandra N, Baldisseri DM, Weber DJ, Protein Sci. 1999 Apr;8(4):800-9. PMID:10211826

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