1b4r

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{{STRUCTURE_1b4r| PDB=1b4r | SCENE= }}
{{STRUCTURE_1b4r| PDB=1b4r | SCENE= }}
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'''PKD DOMAIN 1 FROM HUMAN POLYCYSTEIN-1'''
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===PKD DOMAIN 1 FROM HUMAN POLYCYSTEIN-1===
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==Overview==
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Most cases of autosomal dominant polycystic kidney disease (ADPKD) are the result of mutations in the PKD1 gene. The PKD1 gene codes for a large cell-surface glycoprotein, polycystin-1, of unknown function, which, based on its predicted domain structure, may be involved in protein-protein and protein-carbohydrate interactions. Approximately 30% of polycystin-1 consists of 16 copies of a novel protein module called the PKD domain. Here we show that this domain has a beta-sandwich fold. Although this fold is common to a number of cell-surface modules, the PKD domain represents a distinct protein family. The tenth PKD domain of human and Fugu polycystin-1 show extensive conservation of surface residues suggesting that this region could be a ligand-binding site. This structure will allow the likely effects of missense mutations in a large part of the PKD1 gene to be determined.
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(as it appears on PubMed at http://www.pubmed.gov), where 9889186 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9889186}}
==About this Structure==
==About this Structure==
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1B4R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B4R OCA].
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1B4R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B4R OCA].
==Reference==
==Reference==
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[[Category: Membrane protein]]
[[Category: Membrane protein]]
[[Category: Pkd domain 1 from human polycystein-1]]
[[Category: Pkd domain 1 from human polycystein-1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:04:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:15:37 2008''

Revision as of 15:15, 30 June 2008

Image:1b4r.png

Template:STRUCTURE 1b4r

PKD DOMAIN 1 FROM HUMAN POLYCYSTEIN-1

Template:ABSTRACT PUBMED 9889186

About this Structure

1B4R is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The structure of a PKD domain from polycystin-1: implications for polycystic kidney disease., Bycroft M, Bateman A, Clarke J, Hamill SJ, Sandford R, Thomas RL, Chothia C, EMBO J. 1999 Jan 15;18(2):297-305. PMID:9889186

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