1b7f

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[[Image:1b7f.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1b7f| PDB=1b7f | SCENE= }}
{{STRUCTURE_1b7f| PDB=1b7f | SCENE= }}
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'''SXL-LETHAL PROTEIN/RNA COMPLEX'''
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===SXL-LETHAL PROTEIN/RNA COMPLEX===
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==Overview==
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The Sex-lethal (Sxl) protein of Drosophila melanogaster regulates alternative splicing of the transformer (tra) messenger RNA precursor by binding to the tra polypyrimidine tract during the sex-determination process. The crystal structure has now been determined at 2.6 A resolution of the complex formed between two tandemly arranged RNA-binding domains of the Sxl protein and a 12-nucleotide, single-stranded RNA derived from the tra polypyrimidine tract. The two RNA-binding domains have their beta-sheet platforms facing each other to form a V-shaped cleft. The RNA is characteristically extended and bound in this cleft, where the UGUUUUUUU sequence is specifically recognized by the protein. This structure offers the first insight, to our knowledge, into how a protein binds specifically to a cognate RNA without any intramolecular base-pairing.
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The line below this paragraph, {{ABSTRACT_PUBMED_10217141}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10217141 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10217141}}
==About this Structure==
==About this Structure==
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[[Category: Splicing regulation]]
[[Category: Splicing regulation]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:09:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:27:02 2008''

Revision as of 15:27, 30 June 2008

Image:1b7f.png

Template:STRUCTURE 1b7f

SXL-LETHAL PROTEIN/RNA COMPLEX

Template:ABSTRACT PUBMED 10217141

About this Structure

1B7F is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structural basis for recognition of the tra mRNA precursor by the Sex-lethal protein., Handa N, Nureki O, Kurimoto K, Kim I, Sakamoto H, Shimura Y, Muto Y, Yokoyama S, Nature. 1999 Apr 15;398(6728):579-85. PMID:10217141

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