1b8j

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[[Image:1b8j.gif|left|200px]]
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{{STRUCTURE_1b8j| PDB=1b8j | SCENE= }}
{{STRUCTURE_1b8j| PDB=1b8j | SCENE= }}
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'''ALKALINE PHOSPHATASE COMPLEXED WITH VANADATE'''
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===ALKALINE PHOSPHATASE COMPLEXED WITH VANADATE===
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==Overview==
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A high resolution crystal structure of Escherichia coli alkaline phosphatase in the presence of vanadate has been refined to 1.9 A resolution. The vanadate ion takes on a trigonal bipyramidal geometry and is covalently bound by the active site serine nucleophile. A coordinated water molecule occupies the axial position opposite the serine nucleophile, whereas the equatorial oxygen atoms of the vanadate ion are stabilized by interactions with both Arg-166 and the zinc metal ions of the active site. This structural complex supports the in-line displacement mechanism of phosphomonoester hydrolysis by alkaline phosphatase and provides a model for the proposed transition state in the enzyme-catalyzed reaction.
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(as it appears on PubMed at http://www.pubmed.gov), where 10085061 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10085061}}
==About this Structure==
==About this Structure==
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[[Category: Phosphoric monoester]]
[[Category: Phosphoric monoester]]
[[Category: Vanadate]]
[[Category: Vanadate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:12:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:33:45 2008''

Revision as of 15:33, 30 June 2008

Image:1b8j.png

Template:STRUCTURE 1b8j

ALKALINE PHOSPHATASE COMPLEXED WITH VANADATE

Template:ABSTRACT PUBMED 10085061

About this Structure

1B8J is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

A model of the transition state in the alkaline phosphatase reaction., Holtz KM, Stec B, Kantrowitz ER, J Biol Chem. 1999 Mar 26;274(13):8351-4. PMID:10085061

Page seeded by OCA on Mon Jun 30 18:33:45 2008

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