1b8t

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[[Image:1b8t.gif|left|200px]]
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{{STRUCTURE_1b8t| PDB=1b8t | SCENE= }}
{{STRUCTURE_1b8t| PDB=1b8t | SCENE= }}
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'''SOLUTION STRUCTURE OF THE CHICKEN CRP1'''
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===SOLUTION STRUCTURE OF THE CHICKEN CRP1===
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==Overview==
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The mechanism by which the contractile machinery of muscle is assembled and maintained is not well-understood. Members of the cysteine-rich protein (CRP) family have been implicated in these processes. Three vertebrate CRPs (CRP1-3) that exhibit developmentally regulated muscle-specific expression have been identified. All three proteins are associated with the actin cytoskeleton, and one has been shown to be required for striated muscle structure and function. The vertebrate CRPs identified to date display a similar molecular architecture; each protein is comprised of two tandemly arrayed LIM domains, protein-binding motifs found in a number of proteins with roles in cell differentiation. Each LIM domain coordinates two Zn(II) ions that are bound independently in CCHC (C=Cys, H=His) and CCCC modules. Here we describe the solution structure of chicken CRP1 determined by homonuclear and 1H-15N heteronuclear magnetic resonance spectroscopy. Comparison of the structures of the two LIM domains of CRP1 reveals a high degree of similarity in their tertiary folds. In addition, the two component LIM domains represent two completely independent folding units and exhibit no apparent interactions with each other. The structural independence and spatial separation of the two LIM domains of CRP1 are compatible with an adapter or linker role for the protein.
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(as it appears on PubMed at http://www.pubmed.gov), where 10231520 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10231520}}
==About this Structure==
==About this Structure==
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1B8T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8T OCA].
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1B8T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8T OCA].
==Reference==
==Reference==
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[[Category: Muscle differentiation]]
[[Category: Muscle differentiation]]
[[Category: Nmr]]
[[Category: Nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:13:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:35:04 2008''

Revision as of 15:35, 30 June 2008

Image:1b8t.png

Template:STRUCTURE 1b8t

SOLUTION STRUCTURE OF THE CHICKEN CRP1

Template:ABSTRACT PUBMED 10231520

About this Structure

1B8T is a Single protein structure of sequence from Gallus gallus. Full experimental information is available from OCA.

Reference

Solution structure of the chicken cysteine-rich protein, CRP1, a double-LIM protein implicated in muscle differentiation., Yao X, Perez-Alvarado GC, Louis HA, Pomies P, Hatt C, Summers MF, Beckerle MC, Biochemistry. 1999 May 4;38(18):5701-13. PMID:10231520

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