1b9g

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[[Image:1b9g.gif|left|200px]]
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{{Seed}}
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[[Image:1b9g.png|left|200px]]
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{{STRUCTURE_1b9g| PDB=1b9g | SCENE= }}
{{STRUCTURE_1b9g| PDB=1b9g | SCENE= }}
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'''INSULIN-LIKE-GROWTH-FACTOR-1'''
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===INSULIN-LIKE-GROWTH-FACTOR-1===
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==Overview==
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Mini insulin-like growth factor 1, an inactive insulin-like growth factor 1 mutant lacking the C region, was studied by 2D NMR spectroscopy. Resonances were assigned for almost all protons of the 57 amino acid residues. The 3D structure of the protein was determined by distance geometry methods. Three helical segments; Ala 8-Cys 18, Gly 42-Phe 49, and Leu 54-Cys 61, were identified, corresponding to those present in wild-type insulin-like growth factor 1 and in single-chain insulin. Their relative orientation, however, was found to be changed. This change is connected with a displacement of the Phe 23-Tyr 24-Phe 25-Asn 26 beta-strand-like segment, i.e., of aromatic side chains known to be important for receptor binding. Thus, deletion of the C region of IGF-1 results in a substantial tertiary structural rearrangement that accounts for the loss of receptor affinity.
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The line below this paragraph, {{ABSTRACT_PUBMED_8931138}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8931138 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8931138}}
==About this Structure==
==About this Structure==
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1B9G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B9G OCA].
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1B9G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B9G OCA].
==Reference==
==Reference==
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[[Category: Wollmer, A.]]
[[Category: Wollmer, A.]]
[[Category: Growth factor igf-1]]
[[Category: Growth factor igf-1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:14:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:37:48 2008''

Revision as of 15:37, 30 June 2008

Image:1b9g.png

Template:STRUCTURE 1b9g

INSULIN-LIKE-GROWTH-FACTOR-1

Template:ABSTRACT PUBMED 8931138

About this Structure

1B9G is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of a mini IGF-1., De Wolf E, Gill R, Geddes S, Pitts J, Wollmer A, Grotzinger J, Protein Sci. 1996 Nov;5(11):2193-202. PMID:8931138

Page seeded by OCA on Mon Jun 30 18:37:48 2008

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