1bbd

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{{Seed}}
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{{STRUCTURE_1bbd| PDB=1bbd | SCENE= }}
{{STRUCTURE_1bbd| PDB=1bbd | SCENE= }}
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'''THREE DIMENSIONAL STRUCTURE OF THE FAB FRAGMENT OF A NEUTRALIZING ANTIBODY TO HUMAN RHINOVIRUS SEROTYPE 2'''
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===THREE DIMENSIONAL STRUCTURE OF THE FAB FRAGMENT OF A NEUTRALIZING ANTIBODY TO HUMAN RHINOVIRUS SEROTYPE 2===
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==Overview==
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The crystal structure of the antigen-binding fragment of a monoclonal antibody (8F5) that neutralizes human rhinovirus serotype 2 has been determined by X-ray diffraction studies. Antibody 8F5, obtained by immunization with native HRV2 virions, cross-reacts with peptides of the viral capsid protein VP2, which contribute to the neutralizing immunogenic site B in this serotype. The structure was solved by the molecular replacement method and has been refined to an R-factor of 18.9% at 2.8 A resolution. The elbow angle, relating the variable and constant modules of the molecule is 127 degrees, representing the smallest elbow angle observed so far in an Fab fragment. Furthermore, the charged residues of the epitope can be well accommodated in the antigen-binding site. This is the first crystal structure reported for an antibody directed against an icosahedral virus.
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The line below this paragraph, {{ABSTRACT_PUBMED_1338980}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 1338980 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1338980}}
==About this Structure==
==About this Structure==
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[[Category: Tormo, J.]]
[[Category: Tormo, J.]]
[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:18:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:45:38 2008''

Revision as of 15:45, 30 June 2008

Image:1bbd.png

Template:STRUCTURE 1bbd

THREE DIMENSIONAL STRUCTURE OF THE FAB FRAGMENT OF A NEUTRALIZING ANTIBODY TO HUMAN RHINOVIRUS SEROTYPE 2

Template:ABSTRACT PUBMED 1338980

About this Structure

1BBD is a Protein complex structure. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the Fab fragment of a neutralizing antibody to human rhinovirus serotype 2., Tormo J, Stadler E, Skern T, Auer H, Kanzler O, Betzel C, Blaas D, Fita I, Protein Sci. 1992 Sep;1(9):1154-61. PMID:1338980

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