1bd2

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{{Seed}}
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{{STRUCTURE_1bd2| PDB=1bd2 | SCENE= }}
{{STRUCTURE_1bd2| PDB=1bd2 | SCENE= }}
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'''COMPLEX BETWEEN HUMAN T-CELL RECEPTOR B7, VIRAL PEPTIDE (TAX) AND MHC CLASS I MOLECULE HLA-A 0201'''
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===COMPLEX BETWEEN HUMAN T-CELL RECEPTOR B7, VIRAL PEPTIDE (TAX) AND MHC CLASS I MOLECULE HLA-A 0201===
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==Overview==
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The three-dimensional structure of a human alphabeta T cell receptor (TCR), B7, bound to the HLA-A2 molecule/HTLV-1 Tax peptide complex was determined by x-ray crystallography. Although different from the A6 TCR, previously studied, in 16 of the 17 residues that contact HLA-A2/Tax, the B7 TCR binds in a similar diagonal manner, only slightly tipped and rotated, relative to the A6 TCR. The structure explains data from functional assays on the specificity differences between the B7 and A6 TCRs for agonist, partial agonist, and null peptides. The existence of a structurally similar diagonal binding mode for TCRs favors mechanisms based on the formation of geometrically defined supramolecular assemblies for initiating signaling.
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(as it appears on PubMed at http://www.pubmed.gov), where 9586631 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9586631}}
==About this Structure==
==About this Structure==
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[[Category: Utz, U.]]
[[Category: Utz, U.]]
[[Category: Wiley, D C.]]
[[Category: Wiley, D C.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:21:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:52:16 2008''

Revision as of 15:52, 30 June 2008

Image:1bd2.png

Template:STRUCTURE 1bd2

COMPLEX BETWEEN HUMAN T-CELL RECEPTOR B7, VIRAL PEPTIDE (TAX) AND MHC CLASS I MOLECULE HLA-A 0201

Template:ABSTRACT PUBMED 9586631

About this Structure

1BD2 is a Protein complex structure of sequences from Homo sapiens and Human t-lymphotropic virus 1. Full crystallographic information is available from OCA.

Reference

Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids., Ding YH, Smith KJ, Garboczi DN, Utz U, Biddison WE, Wiley DC, Immunity. 1998 Apr;8(4):403-11. PMID:9586631

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