1bdx

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{{STRUCTURE_1bdx| PDB=1bdx | SCENE= }}
{{STRUCTURE_1bdx| PDB=1bdx | SCENE= }}
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'''E. COLI DNA HELICASE RUVA WITH BOUND DNA HOLLIDAY JUNCTION, ALPHA CARBONS AND PHOSPHATE ATOMS ONLY'''
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===E. COLI DNA HELICASE RUVA WITH BOUND DNA HOLLIDAY JUNCTION, ALPHA CARBONS AND PHOSPHATE ATOMS ONLY===
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==Overview==
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Here we present the crystal structure of the Escherichia coli protein RuvA bound to a key DNA intermediate in recombination, the Holliday junction. The structure, solved by isomorphous replacement and density modification at 6 A resolution, reveals the molecular architecture at the heart of the branch migration and resolution reactions required to process Holliday intermediates into recombinant DNA molecules. It also reveals directly for the first time the structure of the Holliday junction. A single RuvA tetramer is bound to one face of a junction whose four DNA duplex arms are arranged in an open and essentially four-fold symmetric conformation. Protein-DNA contacts are mediated by two copies of a helix-hairpin-helix motif per RuvA subunit that contact the phosphate backbone in a very similar manner. The open structure of the junction stabilized by RuvA binding exposes a DNA surface that could be bound by the RuvC endonuclease to promote resolution.
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(as it appears on PubMed at http://www.pubmed.gov), where 9628481 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9628481}}
==About this Structure==
==About this Structure==
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[[Category: Holliday junction]]
[[Category: Holliday junction]]
[[Category: Ruv]]
[[Category: Ruv]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:23:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:56:02 2008''

Revision as of 15:56, 30 June 2008

Image:1bdx.png

Template:STRUCTURE 1bdx

E. COLI DNA HELICASE RUVA WITH BOUND DNA HOLLIDAY JUNCTION, ALPHA CARBONS AND PHOSPHATE ATOMS ONLY

Template:ABSTRACT PUBMED 9628481

About this Structure

1BDX is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of E.coli RuvA with bound DNA Holliday junction at 6 A resolution., Hargreaves D, Rice DW, Sedelnikova SE, Artymiuk PJ, Lloyd RG, Rafferty JB, Nat Struct Biol. 1998 Jun;5(6):441-6. PMID:9628481

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