1bfc

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[[Image:1bfc.gif|left|200px]]
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{{Seed}}
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[[Image:1bfc.png|left|200px]]
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{{STRUCTURE_1bfc| PDB=1bfc | SCENE= }}
{{STRUCTURE_1bfc| PDB=1bfc | SCENE= }}
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'''BASIC FIBROBLAST GROWTH FACTOR COMPLEXED WITH HEPARIN HEXAMER FRAGMENT'''
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===BASIC FIBROBLAST GROWTH FACTOR COMPLEXED WITH HEPARIN HEXAMER FRAGMENT===
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==Overview==
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Crystal structures of heparin-derived tetra- and hexasaccharides complexed with basic fibroblast growth factor (bFGF) were determined at resolutions of 1.9 and 2.2 angstroms, respectively. The heparin structure may be approximated as a helical polymer with a disaccharide rotation of 174 degrees and a translation of 8.6 angstroms along the helix axis. Both molecules bound similarly to a region of the bFGF surface containing residues asparagine-28, arginine-121, lysine-126, and glutamine-135, the hexasaccharide also interacted with an additional binding site formed by lysine-27, asparagine-102, and lysine-136. No significant conformational change in bFGF occurred upon heparin oligosaccharide binding, which suggests that heparin primarily serves to juxtapose components of the FGF signal transduction pathway.
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(as it appears on PubMed at http://www.pubmed.gov), where 8599088 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8599088}}
==About this Structure==
==About this Structure==
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[[Category: Mitogen]]
[[Category: Mitogen]]
[[Category: Vascularization]]
[[Category: Vascularization]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:26:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:02:00 2008''

Revision as of 16:02, 30 June 2008

Image:1bfc.png

Template:STRUCTURE 1bfc

BASIC FIBROBLAST GROWTH FACTOR COMPLEXED WITH HEPARIN HEXAMER FRAGMENT

Template:ABSTRACT PUBMED 8599088

About this Structure

1BFC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Heparin structure and interactions with basic fibroblast growth factor., Faham S, Hileman RE, Fromm JR, Linhardt RJ, Rees DC, Science. 1996 Feb 23;271(5252):1116-20. PMID:8599088

Page seeded by OCA on Mon Jun 30 19:02:00 2008

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