1bg6

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{{STRUCTURE_1bg6| PDB=1bg6 | SCENE= }}
{{STRUCTURE_1bg6| PDB=1bg6 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE N-(1-D-CARBOXYLETHYL)-L-NORVALINE DEHYDROGENASE FROM ARTHROBACTER SP. STRAIN 1C'''
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===CRYSTAL STRUCTURE OF THE N-(1-D-CARBOXYLETHYL)-L-NORVALINE DEHYDROGENASE FROM ARTHROBACTER SP. STRAIN 1C===
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==Overview==
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Opine dehydrogenases catalyze the NAD(P)H-dependent reversible reaction to form opines that contain two asymmetric centers exhibiting either (L,L) or (D,L) stereochemistry. The first structure of a (D,L) superfamily member, N-(1-D-carboxylethyl)-L-norvaline dehydrogenase (CENDH) from Arthrobacter sp. strain 1C, has been determined at 1.8 A resolution and the location of the bound nucleotide coenzyme has been identified. Six conserved residues cluster in the cleft between the enzyme's two domains, close to the nucleotide binding site, and are presumed to define the enzyme's catalytic machinery. Conservation of a His-Asp pair as part of this cluster suggests that the enzyme mechanism is related to the 2-hydroxy acid dehydrogenases. The pattern of sequence conservation and substitution between members of this enzyme family has permitted the tentative location of the residues that define their differential substrate specificities.
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(as it appears on PubMed at http://www.pubmed.gov), where 9665174 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9665174}}
==About this Structure==
==About this Structure==
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[[Category: Rice, D W.]]
[[Category: Rice, D W.]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:28:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:05:35 2008''

Revision as of 16:05, 30 June 2008

Image:1bg6.png

Template:STRUCTURE 1bg6

CRYSTAL STRUCTURE OF THE N-(1-D-CARBOXYLETHYL)-L-NORVALINE DEHYDROGENASE FROM ARTHROBACTER SP. STRAIN 1C

Template:ABSTRACT PUBMED 9665174

About this Structure

1BG6 is a Single protein structure of sequence from Arthrobacter. Full crystallographic information is available from OCA.

Reference

Crystal structure and active site location of N-(1-D-carboxylethyl)-L-norvaline dehydrogenase., Britton KL, Asano Y, Rice DW, Nat Struct Biol. 1998 Jul;5(7):593-601. PMID:9665174

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