1bh8

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[[Image:1bh8.gif|left|200px]]
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{{Seed}}
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[[Image:1bh8.png|left|200px]]
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{{STRUCTURE_1bh8| PDB=1bh8 | SCENE= }}
{{STRUCTURE_1bh8| PDB=1bh8 | SCENE= }}
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'''HTAFII18/HTAFII28 HETERODIMER CRYSTAL STRUCTURE'''
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===HTAFII18/HTAFII28 HETERODIMER CRYSTAL STRUCTURE===
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==Overview==
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Determination of the crystal structure of the human TBP-associated factor (hTAF(II))28/hTAF(II)18 heterodimer shows that these TAF(II)s form a novel histone-like pair in the TFIID complex. The histone folds in hTAF(II)28 and hTAF(II)18 were not predicted from their primary sequence, indicating that these TAF(II)s define a novel family of atypical histone fold sequences. The TAF(II)18 and TAF(II)28 histone fold motifs are also present in the N- and C-terminal regions of the SPT3 proteins, suggesting that the histone fold in SPT3 may be reconstituted by intramolecular rather than classical intermolecular interactions. The existence of additional histone-like pairs in both the TFIID and SAGA complexes shows that the histone fold is a more commonly used motif for mediating TAF-TAF interactions than previously believed.
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(as it appears on PubMed at http://www.pubmed.gov), where 9695952 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9695952}}
==About this Structure==
==About this Structure==
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[[Category: Tata binding protein]]
[[Category: Tata binding protein]]
[[Category: Transcription regulation complex]]
[[Category: Transcription regulation complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:30:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:09:53 2008''

Revision as of 16:09, 30 June 2008

Image:1bh8.png

Template:STRUCTURE 1bh8

HTAFII18/HTAFII28 HETERODIMER CRYSTAL STRUCTURE

Template:ABSTRACT PUBMED 9695952

About this Structure

1BH8 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family., Birck C, Poch O, Romier C, Ruff M, Mengus G, Lavigne AC, Davidson I, Moras D, Cell. 1998 Jul 24;94(2):239-49. PMID:9695952

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