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1bht

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{{STRUCTURE_1bht| PDB=1bht | SCENE= }}
{{STRUCTURE_1bht| PDB=1bht | SCENE= }}
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'''NK1 FRAGMENT OF HUMAN HEPATOCYTE GROWTH FACTOR'''
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===NK1 FRAGMENT OF HUMAN HEPATOCYTE GROWTH FACTOR===
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==Overview==
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BACKGROUND: Hepatocyte growth factor (HGF) is a mitogen for hepatocytes and has also been implicated as an epithelial morphogen in tumor invasion. HGF activates its specific cellular receptor, c-met, through an aggregation mechanism potentiated by heparan sulfate glycosaminoglycans. HGF consists of an N-terminal (N) domain, four kringle domains (the first of which carries receptor-binding determinants), and an inactive serine-protease-like domain. NK1, a naturally occurring fragment of HGF, acts as an antagonist of HGF in the absence of heparin. RESULTS: The N domain of NK1 consists of a central five-stranded antiparallel beta sheet flanked by an alpha helix and a two-stranded beta ribbon. The overall N domain structure in the context of the NK1 fragment is similar to the structure of the isolated domain; two lysines and an arginine residue coordinate a bound sulfate ion. The NK1 kringle domain is homologous to kringle 4 from plasminogen, except that the lysine-binding pocket is altered by the insertion of a glycine residue. Here, a HEPES molecule is bound in the pocket. The asymmetric unit of the crystal contains a 'head-to-tail' NK1 dimer. We use this dimer to propose a model of the NK2 fragment of HGF. CONCLUSIONS: A cluster of exposed lysine and arginine residues in or near the hairpin-loop region of the N domain might form part of the NK1 heparin-binding site. In our NK2 model, both kringle domains pack loosely against the N domain, and a long, positively charged groove lines the interface. This groove might be involved in glycosaminoglycan binding. The HGF receptor-binding determinants are clustered near the binding pocket of the first kringle domain, opposite the N domain.
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(as it appears on PubMed at http://www.pubmed.gov), where 9817840 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9817840}}
==About this Structure==
==About this Structure==
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[[Category: Heparin-binding domain]]
[[Category: Heparin-binding domain]]
[[Category: Kringle]]
[[Category: Kringle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:31:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:11:30 2008''

Revision as of 16:11, 30 June 2008

Image:1bht.png

Template:STRUCTURE 1bht

NK1 FRAGMENT OF HUMAN HEPATOCYTE GROWTH FACTOR

Template:ABSTRACT PUBMED 9817840

About this Structure

1BHT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0 A resolution., Ultsch M, Lokker NA, Godowski PJ, de Vos AM, Structure. 1998 Nov 15;6(11):1383-93. PMID:9817840

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