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1bij

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[[Image:1bij.gif|left|200px]]
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[[Image:1bij.png|left|200px]]
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{{STRUCTURE_1bij| PDB=1bij | SCENE= }}
{{STRUCTURE_1bij| PDB=1bij | SCENE= }}
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'''CROSSLINKED, DEOXY HUMAN HEMOGLOBIN A'''
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===CROSSLINKED, DEOXY HUMAN HEMOGLOBIN A===
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==Overview==
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The crystal structure of human hemoglobin crosslinked between the Lysbeta82 residues has been determined at 2.30 A resolution. The crosslinking reaction was performed under oxy conditions using bis(3, 5-dibromosalicyl) fumarate; the modified hemoglobin has increased oxygen affinity and lacks cooperativity. Since the crystallization occurred under deoxy conditions, the resulting structure displays conformational characteristics of both the (oxy) R and the (deoxy) T-states. beta82XLHbA does not fully reach its T-state conformation due to the presence of the crosslink. The R-state-like characteristics of deoxy beta82XLHbA include the position of the distal Hisbeta63 (E7) residue, indicating a possible reason for the high oxygen affinity of this derivative. Other areas of the molecule, particularly those thought to be important in the allosteric transition, such as Tyrbeta145 (HC2) and the switch region involving Proalpha(1)44 (CD2), Thralpha(1)41 (C6) and Hisbeta(2)97 (FG4), are in intermediate positions between the R and T-states. Thus, the structure may represent a stabilized intermediate in the allosteric transition of hemoglobin.
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(as it appears on PubMed at http://www.pubmed.gov), where 10698631 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10698631}}
==About this Structure==
==About this Structure==
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[[Category: Heme]]
[[Category: Heme]]
[[Category: Oxygen transport]]
[[Category: Oxygen transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:33:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:13:11 2008''

Revision as of 16:13, 30 June 2008

Image:1bij.png

Template:STRUCTURE 1bij

CROSSLINKED, DEOXY HUMAN HEMOGLOBIN A

Template:ABSTRACT PUBMED 10698631

About this Structure

1BIJ is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of Lysbeta(1)82-Lysbeta(2)82 crosslinked hemoglobin: a possible allosteric intermediate., Fernandez EJ, Abad-Zapatero C, Olsen KW, J Mol Biol. 2000 Mar 10;296(5):1245-56. PMID:10698631

Page seeded by OCA on Mon Jun 30 19:13:11 2008

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