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1bjf

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[[Image:1bjf.jpg|left|200px]]
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{{STRUCTURE_1bjf| PDB=1bjf | SCENE= }}
{{STRUCTURE_1bjf| PDB=1bjf | SCENE= }}
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'''CRYSTAL STRUCTURE OF RECOMBINANT BOVINE NEUROCALCIN DELTA AT 2.4 ANGSTROMS'''
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===CRYSTAL STRUCTURE OF RECOMBINANT BOVINE NEUROCALCIN DELTA AT 2.4 ANGSTROMS===
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==Overview==
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The crystal structure of calcium-bound unmyristoylated bovine neurocalcin from Escherichia coli has been determined at 2.4 A resolution. The three-dimensional structure reveals a highly compact structure consisting of: (i) two pairs of calcium-binding EF-hands (EF1-EF2 and EF3-EF4); (ii) a calcium ion bound at EF2, EF3 and EF4 sites; and (iii) an EF1-hand that is disabled from calcium-binding due to a Cys-Pro sequence in the Ca2+-binding loop. The crystal structure of neurocalcin resembles photoreceptor recoverin in overall topology, however its EF2- and EF4-hands differ. Recently, neurocalcin in the calcium-bound state has been shown to stimulate mammalian rod outer segment membrane guanylate cyclase. A possible site for cyclase activity based on the three-dimensional structure is discussed.
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The line below this paragraph, {{ABSTRACT_PUBMED_9886296}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9886296 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9886296}}
==About this Structure==
==About this Structure==
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[[Category: Myristoylation]]
[[Category: Myristoylation]]
[[Category: Neuronal specific guanylate cyclase activator]]
[[Category: Neuronal specific guanylate cyclase activator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:35:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:15:47 2008''

Revision as of 16:15, 30 June 2008

Image:1bjf.png

Template:STRUCTURE 1bjf

CRYSTAL STRUCTURE OF RECOMBINANT BOVINE NEUROCALCIN DELTA AT 2.4 ANGSTROMS

Template:ABSTRACT PUBMED 9886296

About this Structure

1BJF is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of recombinant bovine neurocalcin., Vijay-Kumar S, Kumar VD, Nat Struct Biol. 1999 Jan;6(1):80-8. PMID:9886296

Page seeded by OCA on Mon Jun 30 19:15:47 2008

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